TANK

Gene Symbol	TANK
Entrez Gene	10010
Alt Symbol	I-TRAF, ITRAF, TRAF2
Species	Human
Gene Type	protein-coding
Description	TRAF family member-associated NFKB activator
Other Description	TRAF family member-associated NF-kappa-B activator|TRAF-interacting protein
Swissprots	Q92844 Q7Z4J6 D3DPB5 Q92885
Accessions	AAX88939 AAY14785 EAX11374 EAX11375 EAX11376 EAX11377 Q92844 AK313096 BAG35920 BC003388 AAH03388 BC067779 AAH67779 BT009855 AAP88857 U59863 AAC50681 U63830 AAC50770 XM_005246207 XP_005246264 XM_005246208 XP_005246265 XM_005246210 XP_005246267 XM_005246211 XP_005246268 XM_011510455 XP_011508757 NM_004180 NP_004171 NM_133484 NP_597841 NM_001199135 NP_001186064
Function	Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Ubiquitous.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TANK CRISPR/Cas9 KO Plasmid (h) - sc-402464 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK HDR Plasmid (h) - sc-402464-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK Double Nickase Plasmid (h) - sc-402464-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK Double Nickase Plasmid (h2) - sc-402464-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK CRISPR Activation Plasmid (h) - sc-402464-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK CRISPR Activation Plasmid (h2) - sc-402464-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK Lentiviral Activation Particles (h) - sc-402464-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK Lentiviral Activation Particles (h2) - sc-402464-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TANK siRNA (h) - sc-36612 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TANK shRNA Plasmid (h) - sc-36612-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TANK shRNA (h) Lentiviral Particles - sc-36612-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TANK RNAi - H00010010-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TANK RNAi - H00010010-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU064531 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK2234 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2233 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2236 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2232 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2231 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2235 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN20994 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20994 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05762 from Sigma-Aldrich Category miRNA

TANK siRNA (Human) - CRH6738 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TANK - MBS8227112 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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