| Gene Symbol |
TANK
|
| Entrez Gene |
10010
|
| Alt Symbol |
I-TRAF, ITRAF, TRAF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRAF family member-associated NFKB activator
|
| Other Description |
TRAF family member-associated NF-kappa-B activator|TRAF-interacting protein
|
| Swissprots |
Q92844 Q7Z4J6 D3DPB5 Q92885
|
| Accessions |
AAX88939 AAY14785 EAX11374 EAX11375 EAX11376 EAX11377 Q92844 AK313096 BAG35920 BC003388 AAH03388 BC067779 AAH67779 BT009855 AAP88857 U59863 AAC50681 U63830 AAC50770 XM_005246207 XP_005246264 XM_005246208 XP_005246265 XM_005246210 XP_005246267 XM_005246211 XP_005246268 XM_011510455 XP_011508757 NM_004180 NP_004171 NM_133484 NP_597841 NM_001199135 NP_001186064
|
| Function |
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|