OPRD1

Gene Symbol OPRD1
Entrez Gene 4985
Alt Symbol OPRD
Species Human
Gene Type protein-coding
Description opioid receptor, delta 1
Other Description D-OR-1|DOR-1|delta opioid receptor 1|delta-type opioid receptor
Swissprots B5B0B8 P41143
Accessions EAX07672 P41143 BC111838 AAI11839 BF434068 EF057065 ABO25742 EU883570 ACG60644 U07882 AAA18789 U10504 AAA83426 NM_000911 NP_000902
Function G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}; Multi- pass membrane protein {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
Tissue Specificity Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. {ECO:0000269|PubMed:22417668, ECO:0000269|PubMed:7808419}.
Top Pathways cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction

Phospho-delta-Opioid Receptor (Ser363) Antibody - 3641 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, stably transfected with δ-opioid receptor (DYKDDDDK-tagged), and either left untreated (lane 1) or treated with 0.1 µM DADLE (lane 2), 1 µM MENK (lane 3) or 1 µM DPDPE (lane 4) for 30 minutes each, using Phospho-δ-Opioid Receptor (Ser363) Antibody (upper) or DYKDDDDK Tag Antibody (Binds to same epitope as Sigma's Anti-FLAG ® M2 Antibody) #2368 (lower).

DOR-1 (M-20) - sc-7492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOR-1 (M-20): sc-7492. Western blot analysis of DOR-1 expression in HUV-EC-C whole cell lysate.

DOR-1 (H-60) - sc-9111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DOR-1 (H-60): sc-9111. Western blot analysis of DOR-1 expression in HUVEC-C (A), NIH/3T3 (B) and U-251-MG (C) whole cell lysates.

DOR-1 (C-20) - sc-7490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DOR-1 (N-18) - sc-7491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Delta Opioid Receptor (phospho S363) antibody - ab62152 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using Delta Opioid Receptor (phospho S363) antibody (ab62152) at 1/50 - 1/100 dilution, in the presence (right panel) and absence (left panel) of immunising phosphopeptide.

Anti-Delta Opioid Receptor antibody - ab66317 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab66317 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab66317, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM

Anti-Delta Opioid Receptor antibody - ab63536 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Delta Opioid Receptor antibody (ab63536) at 1/500 dilutionLane 1 : Extracts from COS7 cells (5-30ug), without immunising peptide.Lane 2 : Extracts from COS7 cells (5-30ug), with immunising peptide (5-10ug).

Anti-Delta Opioid Receptor antibody - ab66318 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Delta Opioid Receptor antibody (ab66318) at 1/500 dilutionLane 1 : human brain lysate at 10 µgLane 2 : rat brain lysate at 10 µgLane 3 : mouse brain lysate at 10 µg

Anti-Delta Opioid Receptor antibody - ab10272 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab10272 at 1/1000 dilution staining Delta Opioid Receptor in transfected cells by Immunocytochemistry.

Anti-Delta Opioid Receptor antibody [EPR5029(2)] - ab176324 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5029(2)
All lanes : Anti-Delta Opioid Receptor antibody [EPR5029(2)] (ab176324) at 1/1000 dilutionLane 1 : Human cerebellum lysateLane 2 : Human fetal brain lysateLane 3 : U87-MG lysateLane 4 : HUVEC lysateLane 5 : SH-SY5Y lysateLysates/proteins at 10 µg per lane.

Anti-OPRD1 / Delta Opioid Receptor Antibody (N-Terminus) IHC-plus™ - LS-A222 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Delta Opioid Receptor antibody LS-A222 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa358-372) - LS-C37871 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa360-372) - LS-C37872 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa360-372) - LS-C37873 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (N-Terminus) - LS-C37874 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) - LS-C37876 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) - LS-C37877 from LifeSpan Bioscience

Prices $635.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) - LS-C37878 from LifeSpan Bioscience

Prices $435.00
Sizes 5 ml
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) - LS-C131132 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) IHC-plus™ - LS-A226 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Delta Opioid Receptor antibody LS-A226 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) IHC-plus™ - LS-A225 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Delta Opioid Receptor antibody LS-A225 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa3-17) - LS-C141820 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Delta Opioid Receptor Antibody - Western blot of DOR-1 with DOR-1 antibody at 1:500 dilution. 10 ug of human brain lysate (lane 1) and rat brain lysate (lane 2).

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa361-372) - LS-C141818 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Delta Opioid Receptor Antibody - Western blot of DOR-1 with DOR-1 antibody at 1:500 dilution. 10 ug of human brain lysate (lane 1), rat brain lysate (lane 2) and mouse brain lysate (lane 3).

Anti-OPRD1 / Delta Opioid Receptor Antibody (aa296-345) - LS-C200299 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HT-29 cells using OPRD1 antibody.
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