| Gene Symbol | OPRD1 |
|---|---|
| Entrez Gene | 4985 |
| Alt Symbol | OPRD |
| Species | Human |
| Gene Type | protein-coding |
| Description | opioid receptor, delta 1 |
| Other Description | D-OR-1|DOR-1|delta opioid receptor 1|delta-type opioid receptor |
| Swissprots | B5B0B8 P41143 |
| Accessions | EAX07672 P41143 BC111838 AAI11839 BF434068 EF057065 ABO25742 EU883570 ACG60644 U07882 AAA18789 U10504 AAA83426 NM_000911 NP_000902 |
| Function | G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}; Multi- pass membrane protein {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}. |
| Tissue Specificity | Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. {ECO:0000269|PubMed:22417668, ECO:0000269|PubMed:7808419}. |
| Top Pathways | cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |
DOR-1 CRISPR/Cas9 KO Plasmid (h) - sc-402195 from Santa Cruz Biotechnology
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DOR-1 HDR Plasmid (h) - sc-402195-HDR from Santa Cruz Biotechnology
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DOR-1 Double Nickase Plasmid (h) - sc-402195-NIC from Santa Cruz Biotechnology
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DOR-1 Double Nickase Plasmid (h2) - sc-402195-NIC-2 from Santa Cruz Biotechnology
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DOR-1 CRISPR Activation Plasmid (h) - sc-402195-ACT from Santa Cruz Biotechnology
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DOR-1 CRISPR Activation Plasmid (h2) - sc-402195-ACT-2 from Santa Cruz Biotechnology
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DOR-1 Lentiviral Activation Particles (h) - sc-402195-LAC from Santa Cruz Biotechnology
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DOR-1 Lentiviral Activation Particles (h2) - sc-402195-LAC-2 from Santa Cruz Biotechnology
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DOR-1 siRNA (h) - sc-42148 from Santa Cruz Biotechnology
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DOR-1 shRNA Plasmid (h) - sc-42148-SH from Santa Cruz Biotechnology
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DOR-1 shRNA (h) Lentiviral Particles - sc-42148-V from Santa Cruz Biotechnology
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delta Opioid R/OPRD1 RNAi - H00004985-R02 from Novus Biologicals
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MISSION® esiRNA - EHU145281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15744 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15744 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04100 from Sigma-Aldrich
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OPRD1 siRNA (Human) - CRH3306 from Cohesion Biosciences
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OPRD1 shRNA Plasmid (Human) - CHH3306 from Cohesion Biosciences
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