| Gene Symbol |
OPRD1
|
| Entrez Gene |
4985
|
| Alt Symbol |
OPRD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
opioid receptor, delta 1
|
| Other Description |
D-OR-1|DOR-1|delta opioid receptor 1|delta-type opioid receptor
|
| Swissprots |
B5B0B8 P41143
|
| Accessions |
EAX07672 P41143 BC111838 AAI11839 BF434068 EF057065 ABO25742 EU883570 ACG60644 U07882 AAA18789 U10504 AAA83426 NM_000911 NP_000902
|
| Function |
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}; Multi- pass membrane protein {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
|
| Tissue Specificity |
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. {ECO:0000269|PubMed:22417668, ECO:0000269|PubMed:7808419}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction
|