Gene Symbol | PROKR1 |
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Entrez Gene | 10887 |
Alt Symbol | GPR73, GPR73a, PKR1, ZAQ |
Species | Human |
Gene Type | protein-coding |
Description | prokineticin receptor 1 |
Other Description | G protein-coupled receptor 73|G protein-coupled receptor ZAQ|G-protein coupled receptor 73|G-protein coupled receptor ZAQ|PK-R1 |
Swissprots | Q8NFJ7 A5JUU2 Q53QT9 Q8TCW9 |
Accessions | AAY24114 EAW99869 Q8TCW9 AB084080 BAC24021 AF506287 AAM48127 AY089976 AAM11892 BC100960 AAI00961 EF577399 ABQ52419 NM_138964 NP_620414 |
Function | Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. {ECO:0000269|PubMed:18339712}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas. {ECO:0000269|PubMed:18339712}. |
PKR1 CRISPR/Cas9 KO Plasmid (h) - sc-409799 from Santa Cruz Biotechnology
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PKR1 HDR Plasmid (h) - sc-409799-HDR from Santa Cruz Biotechnology
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PKR1 Double Nickase Plasmid (h) - sc-409799-NIC from Santa Cruz Biotechnology
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PKR1 Double Nickase Plasmid (h2) - sc-409799-NIC-2 from Santa Cruz Biotechnology
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PKR1 CRISPR Activation Plasmid (h) - sc-409799-ACT from Santa Cruz Biotechnology
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PKR1 CRISPR Activation Plasmid (h2) - sc-409799-ACT-2 from Santa Cruz Biotechnology
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PKR1 Lentiviral Activation Particles (h) - sc-409799-LAC from Santa Cruz Biotechnology
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PKR1 Lentiviral Activation Particles (h2) - sc-409799-LAC-2 from Santa Cruz Biotechnology
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PKR1 siRNA (h) - sc-72361 from Santa Cruz Biotechnology
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PKR1 shRNA Plasmid (h) - sc-72361-SH from Santa Cruz Biotechnology
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PKR1 shRNA (h) Lentiviral Particles - sc-72361-V from Santa Cruz Biotechnology
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Prokineticin R1/PROKR1 RNAi - H00010887-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17458 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17458 from Sigma-Aldrich
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PROKR1 siRNA (Human) - CRH7418 from Cohesion Biosciences
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shRNA set against Human PROKR1(NM_138964.2) - SHR142004 from Creative biogene
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Human PROKR1 siRNA - orb267920 from Biorbyt
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PROKR1 shRNA Plasmid (Human) - CHH7418 from Cohesion Biosciences
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PROKR1 miRNA 3'UTR clone - MiUTR1H-08308 from Creative biogene
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