| Gene Symbol |
HVCN1
|
| Entrez Gene |
84329
|
| Alt Symbol |
HV1, VSOP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydrogen voltage gated channel 1
|
| Other Description |
hydrogen voltage-gated channel 1|voltage sensor domain-only protein|voltage-gated hydrogen channel 1
|
| Swissprots |
A8MQ37 Q6UW11 Q96IS5 B4DEB3 Q96D96 F8WCH5
|
| Accessions |
EAW97933 EAW97934 EAW97935 EAW97936 EAW97937 Q96D96 AK293543 BAG57024 AY359054 AAQ89413 BC007277 AAH07277 BC009731 AAH09731 BC032672 AAH32672 BP369986 BP375483 DB310328 GU211002 ADA61023 JF432642 ADZ15859 XM_005253948 XP_005254005 XM_011538838 XP_011537140 XM_011538839 XP_011537141 XM_011538840 XP_011537142 XM_011538841 XP_011537143 XM_011538842 XP_011537144 XM_011538843 XP_011537145 XM_011538844 XP_011537146 XM_011538845 XP_011537147 XM_011538846 XP_011537148 XM_011538847 XP_011537149 XM_011538848 XP_011537150 NM_001040107 NP_001035196 NM_001256413 NP_001243342 NM_032369 NP_115745
|
| Function |
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:22020278}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
|
| Tissue Specificity |
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. {ECO:0000269|PubMed:16554753}.
|