Gene Symbol | HVCN1 |
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Entrez Gene | 84329 |
Alt Symbol | HV1, VSOP |
Species | Human |
Gene Type | protein-coding |
Description | hydrogen voltage gated channel 1 |
Other Description | hydrogen voltage-gated channel 1|voltage sensor domain-only protein|voltage-gated hydrogen channel 1 |
Swissprots | A8MQ37 Q6UW11 Q96IS5 B4DEB3 Q96D96 F8WCH5 |
Accessions | EAW97933 EAW97934 EAW97935 EAW97936 EAW97937 Q96D96 AK293543 BAG57024 AY359054 AAQ89413 BC007277 AAH07277 BC009731 AAH09731 BC032672 AAH32672 BP369986 BP375483 DB310328 GU211002 ADA61023 JF432642 ADZ15859 XM_005253948 XP_005254005 XM_011538838 XP_011537140 XM_011538839 XP_011537141 XM_011538840 XP_011537142 XM_011538841 XP_011537143 XM_011538842 XP_011537144 XM_011538843 XP_011537145 XM_011538844 XP_011537146 XM_011538845 XP_011537147 XM_011538846 XP_011537148 XM_011538847 XP_011537149 XM_011538848 XP_011537150 NM_001040107 NP_001035196 NM_001256413 NP_001243342 NM_032369 NP_115745 |
Function | Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. {ECO:0000269|PubMed:16554753, ECO:0000269|PubMed:20037153, ECO:0000269|PubMed:22020278}. |
Subcellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types. |
Tissue Specificity | Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. {ECO:0000269|PubMed:16554753}. |
HVCN1 peptide - ab187959 from Abcam
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HVCN1 / HV1 Antibody Blocking Peptide - LS-E7708 from LifeSpan Bioscience
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HVCN1 / HV1 Antibody Blocking Peptide - LS-E30977 from LifeSpan Bioscience
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HVCN1 / HV1 Antibody Blocking Peptide - LS-E12579 from LifeSpan Bioscience
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HVCN1 Peptide - NBP1-76278PEP from Novus Biologicals
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Recombinant Human HVCN1 Protein - H00084329-G01-10ug from Novus Biologicals
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HVCN1-Antibody-N-term-Blocking-Peptide - BP5042a from Abgent, a WuXi AppTec company
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HVCN1 Peptide - GTX85165-PEP from GeneTex
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HVCN1 Peptide - 5875P from ProSci
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HVCN1 fusion protein - Ag5350 from Proteintech Group
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Recombinant Human HVCN1, GST-tagged - HVCN1-14017H from Creative Biomart
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Recombinant Hydrogen Voltage Gated Channel Protein 1 (HVCN1) - RPH843Hu01 from Uscn Life Science Inc.
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Recombinant Hydrogen Voltage Gated Channel Protein 1 (HVCN1) - RPH843Hu01 from Cloud-clone
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HVCN1 / VSOP (transcript variant 2) - TP319422 from Acris Antibodies
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HVCN1 Recombinant Protein Antigen - NBP1-81643PEP from Novus Biologicals
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HVCN1 Peptide, Human - M34GP07363H from Creative Peptides
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