| Gene Symbol | CELF1 |
|---|---|
| Entrez Gene | 10658 |
| Alt Symbol | BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CUGBP, Elav-like family member 1 |
| Other Description | 50 kDa nuclear polyadenylated RNA-binding protein|CELF-1|CUG RNA-binding protein|CUG triplet repeat RNA-binding protein 1|CUG triplet repeat, RNA binding protein 1|CUG triplet repeat, RNA-binding protein 1|CUG-BP- and ETR-3-like factor 1|CUG-BP1|CUGBP Elav-like family member 1|EDEN-BP homolog|RNA-binding protein BRUNOL-2|bruno-like 2|bruno-like protein 2|deadenylation factor CUG-BP|embryo deadenylation element binding protein|embryo deadenylation element-binding protein homolog|nuclear polyadenylated RNA-binding protein, 50-kD |
| Swissprots | Q9NR06 D3DQS0 B4E2U5 Q9NP83 Q4LE52 F8W940 Q92879 |
| Accessions | EAW67906 EAW67907 EAW67908 EAW67909 EAW67910 EAW67911 EAW67912 Q92879 AB210019 BAE06101 AF248648 AAF86230 AF267533 AAF78955 AF267534 AAF78956 AJ007988 CAC20566 AK054655 AK056024 AK057016 AK304430 BAG65257 AK307679 BC031079 AAH31079 BC036782 BM737883 CB960956 DA217269 DA320861 DB162286 DQ893717 ABM84643 U63289 AAC50895 XM_011519847 XP_011518149 XM_011519848 XP_011518150 XM_011519849 XP_011518151 XM_011519850 XP_011518152 XM_011519851 XP_011518153 XM_011519852 XP_011518154 XM_011519853 XP_011518155 XM_011519854 XP_011518156 XM_011519855 XP_011518157 XM_011519856 XP_011518158 XM_011519857 XP_011518159 XM_011519858 XP_011518160 XM_011519859 XP_011518161 NM_001025596 NP_001020767 NM_001172639 NP_001166110 NM_001172640 NP_001166111 NM_006560 NP_006551 NM_198700 NP_941989 |
| Function | RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similar |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:8948631}. Cytoplasm {ECO:0000269|PubMed:8948631}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10893231, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:16862542}. |
CUGBP Elav-like family member 1 (CUGBP1), Human, ELISA Kit - E01C1150 from ARP American Research Products
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CUG triplet repeat, RNA binding protein 1, ELISA Kit - MBS9335861 from MyBioSource
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CUGBP Elav like family member 1 (CUGBP1), ELISA Kit - MBS7203998 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7223048 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7234576 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7227704 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7252542 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7247955 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7220823 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7218010 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7231896 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7239103 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7239366 from MyBioSource
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CUGBP Elav-like family member 1 (CUGBP1), ELISA Kit - MBS7229141 from MyBioSource
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Human CUGBP1 ELISA Kit - E010371 from Biobool
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Human CELF1 ELISA Kit - E010372 from Biobool
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anti-CUG-BP1 antibody - ARG55221 from Arigo Biolaboratories
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