CELF1

Gene Symbol	CELF1
Entrez Gene	10658
Alt Symbol	BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50
Species	Human
Gene Type	protein-coding
Description	CUGBP, Elav-like family member 1
Other Description	50 kDa nuclear polyadenylated RNA-binding protein|CELF-1|CUG RNA-binding protein|CUG triplet repeat RNA-binding protein 1|CUG triplet repeat, RNA binding protein 1|CUG triplet repeat, RNA-binding protein 1|CUG-BP- and ETR-3-like factor 1|CUG-BP1|CUGBP Elav-like family member 1|EDEN-BP homolog|RNA-binding protein BRUNOL-2|bruno-like 2|bruno-like protein 2|deadenylation factor CUG-BP|embryo deadenylation element binding protein|embryo deadenylation element-binding protein homolog|nuclear polyadenylated RNA-binding protein, 50-kD
Swissprots	Q9NR06 D3DQS0 B4E2U5 Q9NP83 Q4LE52 F8W940 Q92879
Accessions	EAW67906 EAW67907 EAW67908 EAW67909 EAW67910 EAW67911 EAW67912 Q92879 AB210019 BAE06101 AF248648 AAF86230 AF267533 AAF78955 AF267534 AAF78956 AJ007988 CAC20566 AK054655 AK056024 AK057016 AK304430 BAG65257 AK307679 BC031079 AAH31079 BC036782 BM737883 CB960956 DA217269 DA320861 DB162286 DQ893717 ABM84643 U63289 AAC50895 XM_011519847 XP_011518149 XM_011519848 XP_011518150 XM_011519849 XP_011518151 XM_011519850 XP_011518152 XM_011519851 XP_011518153 XM_011519852 XP_011518154 XM_011519853 XP_011518155 XM_011519854 XP_011518156 XM_011519855 XP_011518157 XM_011519856 XP_011518158 XM_011519857 XP_011518159 XM_011519858 XP_011518160 XM_011519859 XP_011518161 NM_001025596 NP_001020767 NM_001172639 NP_001166110 NM_001172640 NP_001166111 NM_006560 NP_006551 NM_198700 NP_941989
Function	RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similar
Subcellular Location	Nucleus {ECO:0000269|PubMed:8948631}. Cytoplasm {ECO:0000269|PubMed:8948631}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10893231, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:16862542}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CUG-BP1 CRISPR/Cas9 KO Plasmid (h) - sc-401383 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 HDR Plasmid (h) - sc-401383-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 Double Nickase Plasmid (h) - sc-401383-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 Double Nickase Plasmid (h2) - sc-401383-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 CRISPR Activation Plasmid (h) - sc-401383-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 CRISPR Activation Plasmid (h2) - sc-401383-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 Lentiviral Activation Particles (h) - sc-401383-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 Lentiviral Activation Particles (h2) - sc-401383-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CUG-BP1 siRNA (h) - sc-38251 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CUG-BP1 shRNA Plasmid (h) - sc-38251-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CUG-BP1 shRNA (h) Lentiviral Particles - sc-38251-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CUGBP1/CELF1 RNAi - H00010658-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CUGBP1/CELF1 RNAi - H00010658-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CUGBP1/CELF1 RNAi - H00010658-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU084691 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN5925 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5925 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03936 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03936

CELF1 siRNA (Human) - CRH7266 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CELF1 - MBS8221981 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CELF1 (NM_006560.3) - SHH261477 from Creative biogene Category siRNA Species Reactivities Human

CELF1 shRNA Plasmid (Human) - CHH7266 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CELF1 miRNA 3'UTR clone - MiUTR4H-TG01991 from Creative biogene Species Reactivities Human

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