CELF1

Gene Symbol CELF1
Entrez Gene 10658
Alt Symbol BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50
Species Human
Gene Type protein-coding
Description CUGBP, Elav-like family member 1
Other Description 50 kDa nuclear polyadenylated RNA-binding protein|CELF-1|CUG RNA-binding protein|CUG triplet repeat RNA-binding protein 1|CUG triplet repeat, RNA binding protein 1|CUG triplet repeat, RNA-binding protein 1|CUG-BP- and ETR-3-like factor 1|CUG-BP1|CUGBP Elav-like family member 1|EDEN-BP homolog|RNA-binding protein BRUNOL-2|bruno-like 2|bruno-like protein 2|deadenylation factor CUG-BP|embryo deadenylation element binding protein|embryo deadenylation element-binding protein homolog|nuclear polyadenylated RNA-binding protein, 50-kD
Swissprots Q9NR06 D3DQS0 B4E2U5 Q9NP83 Q4LE52 F8W940 Q92879
Accessions EAW67906 EAW67907 EAW67908 EAW67909 EAW67910 EAW67911 EAW67912 Q92879 AB210019 BAE06101 AF248648 AAF86230 AF267533 AAF78955 AF267534 AAF78956 AJ007988 CAC20566 AK054655 AK056024 AK057016 AK304430 BAG65257 AK307679 BC031079 AAH31079 BC036782 BM737883 CB960956 DA217269 DA320861 DB162286 DQ893717 ABM84643 U63289 AAC50895 XM_011519847 XP_011518149 XM_011519848 XP_011518150 XM_011519849 XP_011518151 XM_011519850 XP_011518152 XM_011519851 XP_011518153 XM_011519852 XP_011518154 XM_011519853 XP_011518155 XM_011519854 XP_011518156 XM_011519855 XP_011518157 XM_011519856 XP_011518158 XM_011519857 XP_011518159 XM_011519858 XP_011518160 XM_011519859 XP_011518161 NM_001025596 NP_001020767 NM_001172639 NP_001166110 NM_001172640 NP_001166111 NM_006560 NP_006551 NM_198700 NP_941989
Function RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similar
Subcellular Location Nucleus {ECO:0000269|PubMed:8948631}. Cytoplasm {ECO:0000269|PubMed:8948631}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10893231, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:16862542}.

CUG-BP1 (3B1) - sc-20003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUG-BP1 (3B1): sc-20003. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

CUG-BP1 (S-16) - sc-21076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUG-BP1 (S-16): sc-21076. Western blot analysis of CUG-BP1 expression in non-transfected 293T: sc-117752 (A), human CUG-BP1 transfected 293T: sc-115438 (B) and HeLa (C) whole cell lysates.

CUG-BP1 (G-19) - sc-23641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CUG-BP1 (1.T.9) - sc-56649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUG-BP1 (1.T.9): sc-56649. Immunofluorescence staining of formalin-fixed Hep G2 cells showing nuclear localization.

CUG-BP1/2 (B-1) - sc-166095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUG-BP1/2 (B-1): sc-166095. Western blot analysis of CUG-BP1 expression in non-transfected 293T: sc-117752 (A), mouse CUG-BP1 transfected 293T: sc-126681 (B) and HeLa (C) whole cell lysates.

CUG-BP1/2 (E-10) - sc-166096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUG-BP1/2 (E-10): sc-166096. Western blot analysis of CUG-BP1 expression in non-transfected: sc-117752 (A) and mouse CUG-BP1 transfected: sc-126681 (B) 293T whole cell lysates.

CUG-BP1/2 (F-1) - sc-166198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUG-BP1/2 (F-1): sc-166198. Western blot analysis of CUG-BP1 expression in non-transfected: sc-117752 (A) and mouse CUG-BP1 transfected: sc-126681 (B) 293T whole cell lysates.

CUG-BP1/2 (H-186) - sc-48822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CUG-BP1/2 (H-186): sc-48822. Western blot analysis of CUG-BP1/2 expression in non-transfected 293T: sc-117752 (A), human CUG-BP1/2 transfected 293T: sc-115438 (B) and HeLa (C) whole cell lysates.

CUG-BP2 (N-17) - sc-54173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CUG-BP1 antibody - ab151593 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CUG-BP1 antibody (ab151593) at 1/1000 dilution + A549 whole cell lysate at 30 µg

Anti-CUG-BP1 antibody - ab69583 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CUG-BP1 antibody (ab69583) at 1/500 dilutionLane 1 : extracts from HeLa cells Lane 2 : extracts from HepG2 cellsLane 3 : extracts from HeLa cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CUG-BP1 antibody - ab116653 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CUG-BP1 antibody (ab116653) at 1/100 dilution + ZR-75-1 cell lysate at 35 µg

Anti-CUG-BP1 antibody [1.T.9] - ab31262 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1.T.9

Anti-CUG-BP1 antibody [3B1] - ab9549 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B1

Anti-CUG-BP1 antibody [5B8] - ab118036 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B8
Overlay histogram showing HeLa cells stained with ab118036 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab118036, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-CUG-BP1 antibody [EPR8298(B)] - ab129115 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8298(B)
All lanes : Anti-CUG-BP1 antibody [EPR8298(B)] (ab129115) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CELF1 / CUGBP1 Antibody (aa1-30, AP) - LS-C213468 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody (aa1-30, Biotin) - LS-C213469 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody (aa1-30, FITC) - LS-C213470 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody (aa1-30, PE) - LS-C213472 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody (aa71-120) - LS-C119189 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/HepG2 cells, using CELF-1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CELF1 / CUGBP1 Antibody (aa1-30, Azide-free, HRP) - LS-C213471 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody - LS-C310034 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody (aa1-30) - LS-C320684 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CELF1 / CUGBP1 Antibody - LS-C334463 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CELF1 antibody.
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