| Gene Symbol |
LPCAT2
|
| Entrez Gene |
54947
|
| Alt Symbol |
AYTL1, LysoPAFAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidylcholine acyltransferase 2
|
| Other Description |
1-AGP acyltransferase 11|1-AGPAT 11|1-acylglycerol-3-phosphate O-acyltransferase 11|1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPAAT-alpha|LPC acyltransferase 2|LPCAT-2|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 2|acyltransferase like 1|acyltransferase-like 1|lyso-PAF acetyltransferase|lyso-platelet-activating factor (PAF) acetyltransferase|lysoPC acyltransferase 2|lysophosphatidic acid acyltransferase alpha
|
| Swissprots |
A3KBM1 Q9NX23 Q6MZJ6 Q7L5N7
|
| Accessions |
CCF76984 EAW82829 Q7L5N7 AB244718 BAF47696 AI915099 AK000488 BAA91199 AK023271 AK126523 AK308386 AW366682 BC002472 AAH02472 BC005981 BG772279 BX641069 CAE46034 EU831434 ACE87121 EU831526 ACE86445 HG508117 XM_005256006 XP_005256063 XM_006721211 XP_006721274 XM_011523169 XP_011521471 NM_017839 NP_060309
|
| Function |
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21498505}.
|
| Top Pathways |
Ether lipid metabolism, Glycerophospholipid metabolism
|
![Western Blot: LPCAT2 Overexpression Lysate (Adult Normal) [NBL1-12649] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LPCAT2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/897_LPCAT2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12649-img0002.jpg)