LPCAT2

Gene Symbol LPCAT2
Entrez Gene 54947
Alt Symbol AYTL1, LysoPAFAT
Species Human
Gene Type protein-coding
Description lysophosphatidylcholine acyltransferase 2
Other Description 1-AGP acyltransferase 11|1-AGPAT 11|1-acylglycerol-3-phosphate O-acyltransferase 11|1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPAAT-alpha|LPC acyltransferase 2|LPCAT-2|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 2|acyltransferase like 1|acyltransferase-like 1|lyso-PAF acetyltransferase|lyso-platelet-activating factor (PAF) acetyltransferase|lysoPC acyltransferase 2|lysophosphatidic acid acyltransferase alpha
Swissprots A3KBM1 Q9NX23 Q6MZJ6 Q7L5N7
Accessions CCF76984 EAW82829 Q7L5N7 AB244718 BAF47696 AI915099 AK000488 BAA91199 AK023271 AK126523 AK308386 AW366682 BC002472 AAH02472 BC005981 BG772279 BX641069 CAE46034 EU831434 ACE87121 EU831526 ACE86445 HG508117 XM_005256006 XP_005256063 XM_006721211 XP_006721274 XM_011523169 XP_011521471 NM_017839 NP_060309
Function Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21498505}.
Top Pathways Ether lipid metabolism, Glycerophospholipid metabolism

LPCAT2 CRISPR/Cas9 KO Plasmid (h) - sc-405849 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 HDR Plasmid (h) - sc-405849-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 Double Nickase Plasmid (h) - sc-405849-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 Double Nickase Plasmid (h2) - sc-405849-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 CRISPR Activation Plasmid (h) - sc-405849-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 CRISPR Activation Plasmid (h2) - sc-405849-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 Lentiviral Activation Particles (h) - sc-405849-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 Lentiviral Activation Particles (h2) - sc-405849-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LPCAT2 siRNA (h) - sc-93397 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LPCAT2 shRNA Plasmid (h) - sc-93397-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LPCAT2 shRNA (h) Lentiviral Particles - sc-93397-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LPCAT2 RNAi - H00054947-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU010331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12648 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12648 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LPCAT2 siRNA (Human) - CRJ0348 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LPCAT2 (NM_017839.4) - SHH333479 from Creative biogene

Category siRNA
Species Reactivities Human

LPCAT2 shRNA Plasmid (Human) - CHJ0348 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LPCAT2 miRNA 3'UTR clone - MiUTR4H-TG05115 from Creative biogene

Species Reactivities Human
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