LPCAT2

Gene Symbol	LPCAT2
Entrez Gene	54947
Alt Symbol	AYTL1, LysoPAFAT
Species	Human
Gene Type	protein-coding
Description	lysophosphatidylcholine acyltransferase 2
Other Description	1-AGP acyltransferase 11|1-AGPAT 11|1-acylglycerol-3-phosphate O-acyltransferase 11|1-acylglycerophosphocholine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|LPAAT-alpha|LPC acyltransferase 2|LPCAT-2|acetyl-CoA:lyso-PAF acetyltransferase|acetyl-CoA:lyso-platelet-activating factor acetyltransferase|acyl-CoA:lysophosphatidylcholine acyltransferase 2|acyltransferase like 1|acyltransferase-like 1|lyso-PAF acetyltransferase|lyso-platelet-activating factor (PAF) acetyltransferase|lysoPC acyltransferase 2|lysophosphatidic acid acyltransferase alpha
Swissprots	A3KBM1 Q9NX23 Q6MZJ6 Q7L5N7
Accessions	CCF76984 EAW82829 Q7L5N7 AB244718 BAF47696 AI915099 AK000488 BAA91199 AK023271 AK126523 AK308386 AW366682 BC002472 AAH02472 BC005981 BG772279 BX641069 CAE46034 EU831434 ACE87121 EU831526 ACE86445 HG508117 XM_005256006 XP_005256063 XM_006721211 XP_006721274 XM_011523169 XP_011521471 NM_017839 NP_060309
Function	Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:20363836, ECO:0000269|PubMed:21498505}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21498505}.
Top Pathways	Ether lipid metabolism, Glycerophospholipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Acyltransferase like 1 full length protein - ab162907 from Abcam Category Protein Source Wheat germ Species Human

LPCAT2 Antibody Blocking Peptide - LS-E17161 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LPCAT2 Antibody Blocking Peptide - LS-E17162 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LPCAT2 Protein - H00054947-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Lpcat2 Blocking Peptide - 33R-6673 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Lpcat2 Blocking Peptide - 33R-4999 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LPCAT2 / AYTL1 - H00054947-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LPCAT2 / AYTL1 - H00054947-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LPCAT2 fusion protein - Ag7156 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

LPCAT2 fusion protein - Ag7079 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human LPCAT2, GST-tagged - LPCAT2-621H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) - RPG530Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) - RPG530Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) - RPG530Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Lysophosphatidylcholine Acyltransferase 2 (LPCAT2) - RPG530Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Lysophosphatidylcholine acyltransferase 2(LPCAT2) - CSB-YP013053HU CSB-EP013053HU CSB-BP013053HU CSB-MP013053HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LPCAT2 / AYTL1 - TP300168 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LPCAT2 Recombinant Protein Antigen - NBP1-88921PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LPCAT2 Peptide, Human - M34GP08812H from Creative Peptides Category Peptide Source Synthetic. Species Human

LPCAT2 fusion protein - Ag26420 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

LPCAT2 fusion protein - Ag26411 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Lysophosphatidylcholine acyltransferase 2 (LPCAT2), Recombinant Protein - MBS1315900 from MyBioSource Category Protein Prices $785.00, $785.00, $1,010.00, $1,010.00, $1,090.00, $1,090.00, $1,550.00, $1,550.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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