LPCAT2

Gene Symbol	LPCAT2
Entrez Gene	54947
Alt Symbol	AYTL1, LysoPAFAT
Species	Human
Gene Type	protein-coding
Description	lysophosphatidylcholine acyltransferase 2
Other Description	1-AGP acyltransferase 11\|1-AGPAT 11\|1-acylglycerol-3-phosphate O-acyltransferase 11\|1-acylglycerophosphocholine O-acyltransferase\|1-alkylglycerophosphocholine O-acetyltransferase\|LPAAT-alpha\|LPC acyltransferase 2\|LPCAT-2\|acetyl-CoA:lyso-PAF acetyltransferase\|acetyl-CoA:lyso-platelet-activating factor acetyltransferase\|acyl-CoA:lysophosphatidylcholine acyltransferase 2\|acyltransferase like 1\|acyltransferase-like 1\|lyso-PAF acetyltransferase\|lyso-platelet-activating factor (PAF) acetyltransferase\|lysoPC acyltransferase 2\|lysophosphatidic acid acyltransferase alpha
Swissprots	A3KBM1 Q9NX23 Q6MZJ6 Q7L5N7
Accessions	CCF76984 EAW82829 Q7L5N7 AB244718 BAF47696 AI915099 AK000488 BAA91199 AK023271 AK126523 AK308386 AW366682 BC002472 AAH02472 BC005981 BG772279 BX641069 CAE46034 EU831434 ACE87121 EU831526 ACE86445 HG508117 XM_005256006 XP_005256063 XM_006721211 XP_006721274 XM_011523169 XP_011521471 NM_017839 NP_060309
Function	Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3- phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2- diacyl-sn-glycero-3-phosphocholine. {ECO:0000269\|PubMed:20363836, ECO:0000269\|PubMed:21498505}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269\|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000269\|PubMed:21498505}.
Top Pathways	Ether lipid metabolism, Glycerophospholipid metabolism

LPCAT2 (H-7) - sc-514354 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

LPCAT2 (H-7): sc-514354. Western blot analysis of LPCAT2 expression in non-transfected: sc-117752 (A) and human LPCAT2 transfected: sc-177480 (B) 293T whole cell lysates.

LPCAT2 (C-14) - sc-164904 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

LPCAT2 (C-14): sc-164904. Western blot analysis of LPCAT2 expression in LPS/PMA treated RAW 264.7 whole cell lysate (A) and mouse pancreas tissue exract (B).

LPCAT2 (S-14) - sc-164905 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Acyltransferase like 1 antibody - ab88871 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-Acyltransferase like 1 antibody (ab88871) at 1 µg/ml + Human pancreas tissue lysate at 50 µg

Anti-Acyltransferase like 1 antibody - ab199793 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Acyltransferase like 1 antibody (ab199793) at 1/1000 dilution + A549 cell lysate at 35 µgSecondarygoat anti-rabbit IgG H&L(HRP) at 1/500 dilution

Anti-Acyltransferase like 1 antibody - ab137288 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Acyltransferase like 1 antibody (ab137288) at 1/500 dilution + HT29 cell lysate at 30 µg

Anti-LPCAT2 Antibody (aa318-367) - LS-C292157 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-LPCAT2 Antibody - LS-C309182 from LifeSpan Bioscience

Prices	$455.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Anti-LPCAT2 Antibody (aa461-510) - LS-C145269 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LPCAT2 antibody LS-C145269 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-LPCAT2 Antibody (aa167-216) - LS-C145270 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

LPCAT2 antibody LS-C145270 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-LPCAT2 Antibody (aa321-370) - LS-C119697 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from K562/HT-29 cells, using LPCAT2 Antibody. The lane on the right is treated with the synthesized peptide.

LPCAT2 Antibody - NBP1-88921 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: LPCAT2 Antibody [NBP1-88921] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

LPCAT2 Antibody - H00054947-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: LPCAT2 Antibody [H00054947-B01P] - Analysis of AYTL1 expression in human pancreas.

LPCAT2 Antibody - H00054947-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: LPCAT2 Antibody [H00054947-B01] - AYTL1 MaxPab polyclonal antibody. Western Blot analysis of AYTL1 expression in human pancreas.

LPCAT2 Polyclonal Antibody - bs-10742R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

$Formalin-fixed and paraffin embedded labeled with Rabbit Anti-LPCAT2 Polyclonal Antibody, Unconjugated (bs-10742R) at 1:200 followed by conjugation to the secondary antibody and DAB staining \\n$

Anti-LPCAT2 (201-215) antibody produced in rabbit - SAB1105112 from Sigma-Aldrich

Prices	$279.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-LPCAT2 antibody produced in rabbit - HPA007891 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-AYTL1: <B>Cat. No. HPA007891</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex shows strong cytoplasmic positivity positivity in neuronal cells.

Anti-LPCAT2 antibody produced in rabbit - SAB4502278 from Sigma-Aldrich

Prices	$335.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-LPCAT2: <B>Cat. No. SAB4502278</B>: Immunoblotting analysis of extracts from K562/HT-29 cells, using Anti-LPCAT2 antibody. The lane on the left was treated with the Anti-LPCAT2 antibody. The lane on the right (negative control) was treated with both Anti-LPCAT2 antibody and the synthesized immunogen peptide.

Anti-LPCAT2 (526-540) antibody produced in rabbit - SAB1105113 from Sigma-Aldrich

Prices	$279.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

LPCAT2-Antibody - AP50790 from Abgent, a WuXi AppTec company

Prices	$295.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of lysate from A549 cell line,using LPCAT2 Antibody(AP50790). AP50790 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

LPCAT2 antibody - GTX86989 from GeneTex

Prices	$319.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

Anti-LPCAT2 antibody used in Western blot. GTX86989

LPCAT2 Antibody (OAAB18583) - OAAB18583 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

LPCAT2 Antibody (OAAF03232) - OAAF03232 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

LPCAT2 Antibody (OAAF06583) - OAAF06583 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

LPCAT2 antibody - orb161636 from Biorbyt

Prices	$281.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

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