U2AF1L4

Gene Symbol	U2AF1L4
Entrez Gene	199746
Alt Symbol	U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26
Species	Human
Gene Type	protein-coding
Description	U2 small nuclear RNA auxiliary factor 1-like 4
Other Description	U2 auxiliary factor 26|U2 small nuclear RNA auxiliary factor 1-like 3|U2 small nuclear RNA auxiliary factor 1-like protein 3|U2 small nuclear RNA auxiliary factor 1-like protein 4|U2(RNU2) small nuclear RNA auxiliary factor 1-like 3|U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3|U2AF1-like 4|U2AF1-like protein 3|splicing factor U2AF 26 kDa subunit
Swissprots	Q56UU3 A6NKI8 Q8WU68
Accessions	Q8WU68 AI767079 AK092844 BAC03988 AK094213 AK303983 BAG64901 AY461582 AY569437 AAT72770 BC010865 BC021186 AAH21186 BC049208 BC062474 BM696851 CD175846 DC415103 DQ892422 ABM83348 DQ895636 ABM86562 NM_001040425 NP_001035515 NM_144987 NP_659424 NR_110171 NR_110172 NR_110173
Function	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}.
Tissue Specificity	Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

U2AF1L4-Over-expression-Lysate - LY15162a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

U2AF1L4 293T Cell Transient Overexpression Lysate(Denatured) - H00199746-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

U2AF1L4 overexpression lysate - LY408126 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

U2AF1L4 overexpression lysate - LY421747 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

U2AF1L4 overexpression lysate - LY425706 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

U2AF1L4 293 Cell Lysate - 404516 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

U2AF1L4 Overexpression Lysate (Denatured) - H00199746-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

U2AF1L4 Overexpression Lysate (Native) - NBL1-17492 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

U2AF1L4 Over-expression Lysate Product - GWB-CA2713 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human U2AF1L4 Knockdown Stable Cell Line - CSC-DC016923 from Creative biogene Category Cell Line Species Human

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