U2AF1L4

Gene Symbol	U2AF1L4
Entrez Gene	199746
Alt Symbol	U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26
Species	Human
Gene Type	protein-coding
Description	U2 small nuclear RNA auxiliary factor 1-like 4
Other Description	U2 auxiliary factor 26|U2 small nuclear RNA auxiliary factor 1-like 3|U2 small nuclear RNA auxiliary factor 1-like protein 3|U2 small nuclear RNA auxiliary factor 1-like protein 4|U2(RNU2) small nuclear RNA auxiliary factor 1-like 3|U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3|U2AF1-like 4|U2AF1-like protein 3|splicing factor U2AF 26 kDa subunit
Swissprots	Q56UU3 A6NKI8 Q8WU68
Accessions	Q8WU68 AI767079 AK092844 BAC03988 AK094213 AK303983 BAG64901 AY461582 AY569437 AAT72770 BC010865 BC021186 AAH21186 BC049208 BC062474 BM696851 CD175846 DC415103 DQ892422 ABM83348 DQ895636 ABM86562 NM_001040425 NP_001035515 NM_144987 NP_659424 NR_110171 NR_110172 NR_110173
Function	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}.
Tissue Specificity	Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human U2AF1L3 full length protein - ab165852 from Abcam Category Protein Source Wheat germ Species Human

Human U2AF1L3 protein fragment - ab165853 from Abcam Category Protein Source Wheat germ Species Human

U2AF1L4 Antibody Blocking Peptide - LS-E26518 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

U2AF1L4 Partial Recombinant Protein - H00199746-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

U2AF1L4 Recombinant Protein - H00199746-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human U2AF1L4 Protein - NBP2-22915 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

U2AF1L4 blocking peptide - GTX88491-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

U2AF1L3 Peptide - AC21-1354-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

U2AF1L4 / U2AF1L3 - H00199746-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

U2AF1L4 / U2AF1L3 - H00199746-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

U2AF1L4 / U2AF1L3 - H00199746-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

U2AF1L4 / U2AF1L3 - H00199746-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

U2AF1L4 Peptide - 46-759P from ProSci Category Peptide Species Human

U2AF1L4 fusion protein - ag10979 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

U2AF1L4 fusion protein - Ag10949 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human U2AF1L4, GST-tagged - U2AF1L4-3512H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Splicing factor U2AF 26 kDa subunit(U2AF1L4) - CSB-YP837850HU CSB-EP837850HU CSB-BP837850HU CSB-MP837850HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

U2AF1L4 / U2AF1L3 (full length, N-term HIS tag, transcript variant 2) - TP760572 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

U2AF1L4, Peptide - MBS425942 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

U2AF4-Antibody-N-term-Blocking-peptide - BP10274a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

U2AF1L4 Peptide, Human - M34GP16923H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human U2AF1L4 protein - orb54460 from Biorbyt Category Protein Prices $289.00, $408.00, $476.00, $765.00, $1,275.00, $2,023.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg, 500 μg, 1 mg Species Human

U2AF1L4 Recombinant Protein Antigen - NBP2-55898PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Splicing factor U2AF 26 kDa subunit (U2AF1L4), Recombinant Protein - MBS1375574 from MyBioSource Category Protein Prices $970.00, $970.00, $1,195.00, $1,195.00, $1,460.00, $1,460.00, $1,925.00, $1,925.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

U2AF1L4 Recombinant Protein (Human) (OPCA04947) - OPCA04947 from Aviva Systems Biology Category Protein Species Human

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