| Gene Symbol |
U2AF1L4
|
| Entrez Gene |
199746
|
| Alt Symbol |
U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
U2 small nuclear RNA auxiliary factor 1-like 4
|
| Other Description |
U2 auxiliary factor 26|U2 small nuclear RNA auxiliary factor 1-like 3|U2 small nuclear RNA auxiliary factor 1-like protein 3|U2 small nuclear RNA auxiliary factor 1-like protein 4|U2(RNU2) small nuclear RNA auxiliary factor 1-like 3|U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3|U2AF1-like 4|U2AF1-like protein 3|splicing factor U2AF 26 kDa subunit
|
| Swissprots |
Q56UU3 A6NKI8 Q8WU68
|
| Accessions |
Q8WU68 AI767079 AK092844 BAC03988 AK094213 AK303983 BAG64901 AY461582 AY569437 AAT72770 BC010865 BC021186 AAH21186 BC049208 BC062474 BM696851 CD175846 DC415103 DQ892422 ABM83348 DQ895636 ABM86562 NM_001040425 NP_001035515 NM_144987 NP_659424 NR_110171 NR_110172 NR_110173
|
| Function |
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}.
|
| Tissue Specificity |
Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}.
|
| Top Pathways |
Spliceosome
|