U2AF1L4
| Gene Symbol | U2AF1L4 |
|---|---|
| Entrez Gene | 199746 |
| Alt Symbol | U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26 |
| Species | Human |
| Gene Type | protein-coding |
| Description | U2 small nuclear RNA auxiliary factor 1-like 4 |
| Other Description | U2 auxiliary factor 26|U2 small nuclear RNA auxiliary factor 1-like 3|U2 small nuclear RNA auxiliary factor 1-like protein 3|U2 small nuclear RNA auxiliary factor 1-like protein 4|U2(RNU2) small nuclear RNA auxiliary factor 1-like 3|U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3|U2AF1-like 4|U2AF1-like protein 3|splicing factor U2AF 26 kDa subunit |
| Swissprots | Q56UU3 A6NKI8 Q8WU68 |
| Accessions | Q8WU68 AI767079 AK092844 BAC03988 AK094213 AK303983 BAG64901 AY461582 AY569437 AAT72770 BC010865 BC021186 AAH21186 BC049208 BC062474 BM696851 CD175846 DC415103 DQ892422 ABM83348 DQ895636 ABM86562 NM_001040425 NP_001035515 NM_144987 NP_659424 NR_110171 NR_110172 NR_110173 |
| Function | RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Subcellular Location | Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}. |
| Tissue Specificity | Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}. |
| Top Pathways | Spliceosome |
U2AF1L3 CRISPR/Cas9 KO Plasmid (h) - sc-414979 from Santa Cruz Biotechnology
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U2AF1L3 HDR Plasmid (h) - sc-414979-HDR from Santa Cruz Biotechnology
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U2AF1L3 Double Nickase Plasmid (h) - sc-414979-NIC from Santa Cruz Biotechnology
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U2AF1L3 Double Nickase Plasmid (h2) - sc-414979-NIC-2 from Santa Cruz Biotechnology
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U2AF1L3 CRISPR Activation Plasmid (h) - sc-414979-ACT from Santa Cruz Biotechnology
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U2AF1L3 CRISPR Activation Plasmid (h2) - sc-414979-ACT-2 from Santa Cruz Biotechnology
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U2AF1L3 Lentiviral Activation Particles (h) - sc-414979-LAC from Santa Cruz Biotechnology
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U2AF1L3 Lentiviral Activation Particles (h2) - sc-414979-LAC-2 from Santa Cruz Biotechnology
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U2AF1L3 siRNA (h) - sc-97741 from Santa Cruz Biotechnology
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U2AF1L3 shRNA Plasmid (h) - sc-97741-SH from Santa Cruz Biotechnology
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U2AF1L3 shRNA (h) Lentiviral Particles - sc-97741-V from Santa Cruz Biotechnology
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U2AF1L4 RNAi - H00199746-R01 from Novus Biologicals
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MISSION® esiRNA - EHU124391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22330 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22330 from Sigma-Aldrich
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U2AF1L4 siRNA (Human) - CRJ6217 from Cohesion Biosciences
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U2AF1L4 - MBS8223211 from MyBioSource |
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U2AF1L4 - MBS8239604 from MyBioSource |
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U2AF1L4 - MBS8240887 from MyBioSource |
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shRNA set against Human U2AF1L4 (NM_144987.2) - SHH438564 from Creative biogene
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shRNA set against Human U2AF1L4(NM_001040425.1) - SHL109110 from Creative biogene
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shRNA set against Human U2AF1L4(NM_144987.2) - SHL109164 from Creative biogene
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U2AF1L4 shRNA Plasmid (Human) - CHJ6217 from Cohesion Biosciences
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U2AF1L4 miRNA 3'UTR clone - MiUTR1H-10915 from Creative biogene
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U2AF1L4 miRNA 3'UTR clone - MiUTR1H-10916 from Creative biogene
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