U2AF1L4

Gene Symbol U2AF1L4
Entrez Gene 199746
Alt Symbol U2AF1-RS3, U2AF1L3, U2AF1L3V1, U2AF1RS3, U2af26
Species Human
Gene Type protein-coding
Description U2 small nuclear RNA auxiliary factor 1-like 4
Other Description U2 auxiliary factor 26|U2 small nuclear RNA auxiliary factor 1-like 3|U2 small nuclear RNA auxiliary factor 1-like protein 3|U2 small nuclear RNA auxiliary factor 1-like protein 4|U2(RNU2) small nuclear RNA auxiliary factor 1-like 3|U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3|U2AF1-like 4|U2AF1-like protein 3|splicing factor U2AF 26 kDa subunit
Swissprots Q56UU3 A6NKI8 Q8WU68
Accessions Q8WU68 AI767079 AK092844 BAC03988 AK094213 AK303983 BAG64901 AY461582 AY569437 AAT72770 BC010865 BC021186 AAH21186 BC049208 BC062474 BM696851 CD175846 DC415103 DQ892422 ABM83348 DQ895636 ABM86562 NM_001040425 NP_001035515 NM_144987 NP_659424 NR_110171 NR_110172 NR_110173
Function RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q8BGJ9}. Nucleus speckle {ECO:0000250|UniProtKB:Q8BGJ9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BGJ9}. Note=Interaction with C1QBP is required for the nuclear translocation. Displays active nucleo- cytoplasmic shuttling. {ECO:0000250|UniProtKB:Q8BGJ9}.
Tissue Specificity Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:17312947}.
Top Pathways Spliceosome

Anti-U2AF1L3 antibody - ab73033 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-U2AF1L3 antibody (ab73033) at 1/500 dilutionLane 1 : U2AF1L3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-U2AF1L3 antibody - ab80607 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-U2AF1L3 antibody (ab80607) at 0.1 µg/ml + Human Cerebellum lysate (in RIPA buffer) at 35 µg

Anti-U2AF1L3 antibody - ab183649 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of 4% paraformaldehyde-fixed HCT116 cells labeling U2AF1L3 with ab183649 at 1/500 dilution (green). Right panel is also stained with Hoechst 33342 (blue).

Anti-U2AF1L3 antibody [EPR14349] - ab188582 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14349
Immunofluorescent analysis of paraformaldehyde-fixed U87-MG cells labeling U2AF1L3 with ab188582 at 1/250 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green) and DAPI staining.

Anti-U2AF1L4 Antibody - LS-C346252 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of A549 cell using U2AF1L4 antibody. Blue: DAPI for nuclear staining.

Anti-U2AF1L4 Antibody (aa23-72) - LS-C201383 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. U2AF1L4 antibody dilution 1.0 ug/ml.

Anti-U2AF1L4 Antibody (aa82-94) - LS-C87227 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence

U2AF1L4 Antibody - H00199746-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: U2AF1L4 Antibody [H00199746-B01] - analysis of U2AF1L3 expression in transfected 293T cell line by U2AF1L3 MaxPab polyclonal antibody (B01). Lane 1: U2AF1L3 transfected lysate (22.00 KDa). Lane 2: Non-transfected lysate.

U2AF1L4 Antibody - NBP1-06996 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: U2AF1L4 Antibody [NBP1-06996] - Analysis of U2AF1L4 in Human Cerebellum lysate (35ug protein in RIPA buffer) using NBP1-06996 at 0.1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

U2AF1L4 Antibody - H00199746-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

U2AF1L4 Antibody - H00199746-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-U2AF1L4 antibody produced in rabbit - HPA046378 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-U2AF1L4: <B>Cat. No. HPA046378</B>: Immunohistochemical staining of human skin shows strong cytoplasmic positivity in superficial layers of keratinocytes.

Anti-U2AF1L3 antibody produced in mouse - SAB1400839 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-U2AF1L3, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400839</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

Anti-U2AF1L4 antibody produced in goat - SAB2501078 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-U2AF1L4: <B>Cat. No. SAB2501078</B>: (0.1 μg/mL) staining of Human Cerebellum lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-U2AF1L4 (123-135) antibody produced in rabbit - SAB1103417 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human U2AF1L4 was separated on SDS-PAGE, blotted with Anti-U2AF1L4 (123-135) (<B>Cat. No. SAB1103417</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

U2AF1L4 Antibody - N-terminal region (ARP40325_P050) - ARP40325_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

U2AF1L4-Antibody - AF2128a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2128a (0.1 µg/ml) staining of Human Cerebellum lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

U2AF1L4 Antibody (OAEB01867) - OAEB01867 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

U2AF1L4 Polyclonal Antibody - A7151 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using U2AF1L4 antibody. Blue: DAPI for nuclear staining.

U2AF1L4 Antibody - abx036583 from Abbexa

Host Rabbit
Clonality Polyclonal

U2AF1L4 Antibody - abx005397 from Abbexa

Host Rabbit
Clonality Polyclonal

U2AF1L4 / U2AF1L3 antibody - AP16885PU-N from Acris Antibodies

Prices $310.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1µg/ml) staining of Human Cerebellum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

U2AF1L4 / U2AF1L3 antibody - H00199746-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

U2AF1L4 / U2AF1L3 antibody - H00199746-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of U2AF1L4 expression in transfected 293T cell line (H00199746-T01) by U2AF1L4 MaxPab polyclonal antibody.Lane 1: U2AF1
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