EPHB4

Gene Symbol EPHB4
Entrez Gene 2050
Alt Symbol HTK, MYK1, TYRO11
Species Human
Gene Type protein-coding
Description EPH receptor B4
Other Description ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK
Swissprots B5A970 P54760 B5A971 Q7Z635 Q9BXP0 Q9BTA5 B5A972
Accessions AAK21010 AAL14194 CAT16953 EAL23820 EAW76468 EAW76469 EAW76470 P54760 AB209644 BAD92881 AK301224 BAG62797 AY056048 AAL14195 BC004264 AAH04264 BC052804 AAH52804 CB962032 EU826608 ACF47644 EU826609 ACF47645 EU826610 ACF47646 U07695 AAA20598 NM_004444 NP_004435
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
Tissue Specificity Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
Top Pathways Axon guidance

EphB4 (H-10) - sc-365510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EphB4 (H-10): sc-365510. Western blot analysis of EphB4 expression in HeLa whole cell lysate.

EphB4 (C-16)-R - sc-7284-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

EphB4 (H-200) - sc-5536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphB4 (H-200): sc-5536. Western blot analysis of EphB4 expression in human placenta tissue extract.

EphB4 (5G2F8) - sc-130081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

EphB4 (4A12G8) - sc-130062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

EphB4 (N-19) - sc-7285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EphB4 (N-19): sc-7285. Immunoperoxidase staining of formalin fixed, paraffin-embedded human seminal vesicle tissue showing cytoplasmic staining of glandular cells.

EphB4 (U-200) - sc-130753 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EphB4 (U-200): sc-130753. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing membrane localization.

Anti-Eph receptor B4 antibody - ab64820 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor B4 antibody (ab64820) at 1/500 dilutionLane 1 : 293 cell extract at 30 µgLane 2 : Jurkat cell extract at 30 µgLane 3 : immunising peptide at 10 µg

Anti-Eph receptor B4 antibody - ab76657 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor B4 antibody (ab76657) at 1/100 dilutionLane 1 : Whole cell lysate prepared from non-transfected 293 cells.Lane 2 : Whole cell lysate prepared from EPB4 transfected 293 cells.Lysates/proteins at 2 µg per lane.

Anti-EPHB4 / EPH Receptor B4 Antibody (C-Terminus) - LS-C23128 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (aa566-578) - LS-C54794 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (C-Terminus, clone 3D7G8) - LS-C23129 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D7G8

Anti-EPHB4 / EPH Receptor B4 Antibody (Extracellular Domain) - LS-C125538 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (clone VEB-7E4) - LS-C139929 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone VEB-7E4

Anti-EPHB4 / EPH Receptor B4 Antibody (clone 67CT23.5.8) - LS-C96483 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 67CT23.5.8
Western blot of anti-EPHB4 Monoclonal Antibody by EPHB4 recombinant protein(Fragment). EPHB4 protein (arrow) was detected using the purified antibody.

Anti-EPHB4 / EPH Receptor B4 Antibody (aa571-620) - LS-C118944 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat/293 cells, using EPHB4 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-EPHB4 / EPH Receptor B4 Antibody (clone 7H4A6) - LS-C108804 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H4A6
Western blot using EphB4 mouse monoclonal antibody against Jurkat (1) and HEK293 (2) cell lysate.

Anti-EPHB4 / EPH Receptor B4 Antibody (aa16-539) - LS-C149937 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
EphB4 in Human Kidney. EphB4 was detected in immersion fixed paraffin-embedded sections of human kidney using 15 ug/ml Human EphB4 Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Anti-EPHB4 / EPH Receptor B4 Antibody - LS-C100287 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with the EphB4 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-EPHB4 / EPH Receptor B4 Antibody (aa16-539) - LS-C150191 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
EphB4 in Mouse Embryo. EphB4 was detected in immersion fixed frozen sections of mouse embryo (15 d. p. c.) using Goat Anti-Mouse EphB4 Antigen Affinity-purified Polyclonal Antibody at 15 ug/ml overnight at 4°C. Tissue was stained using Anti-Goat HRP-DAB (brown and counterstained with hematoxylin (blue).

Anti-EPHB4 / EPH Receptor B4 Antibody (clone 5B8F7) - LS-C108803 from LifeSpan Bioscience

Prices $260.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5B8F7
IHC of paraffin-embedded Human pancreas carcinoma (left) and breast carcinoma (right) tissue, showing membrane and cytoplasmic (pancreas carcinoma) localization, membrane (breast carcinoma) localization using EphB4 mouse

Anti-EPHB4 / EPH Receptor B4 Antibody (N-Terminus) - LS-C203249 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (aa359-389, AP) - LS-C256752 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (aa359-389, APC) - LS-C256751 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHB4 / EPH Receptor B4 Antibody (aa359-389, Biotin) - LS-C256753 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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