EPHB4

Gene Symbol	EPHB4
Entrez Gene	2050
Alt Symbol	HTK, MYK1, TYRO11
Species	Human
Gene Type	protein-coding
Description	EPH receptor B4
Other Description	ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK
Swissprots	B5A970 P54760 B5A971 Q7Z635 Q9BXP0 Q9BTA5 B5A972
Accessions	AAK21010 AAL14194 CAT16953 EAL23820 EAW76468 EAW76469 EAW76470 P54760 AB209644 BAD92881 AK301224 BAG62797 AY056048 AAL14195 BC004264 AAH04264 BC052804 AAH52804 CB962032 EU826608 ACF47644 EU826609 ACF47645 EU826610 ACF47646 U07695 AAA20598 NM_004444 NP_004435
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
Tissue Specificity	Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan ® EphB4 Kinase Assay Kit - 7719 from Cell Signaling Technology Category Assay Kit

Mouse EPHB4 / EPH Receptor B4 ELISA Kit (Sandwich ELISA) - LS-F11380 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 31.2-2000 pg/ml

Phosphotyrosine EPHB4 / Ephrin Type-B Receptor 4 ELISA Kit - RAB0952 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Phospho-EphB4 DuoSet IC ELISA - DYC4057-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)

Human Phospho-EphB4 DuoSet IC, 5 Plate - DYC4057-5 from R&D Systems Category ELISA Kit

Human Total EphB4 DuoSet IC ELISA - DYC3038-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human Total EphB4 DuoSet IC, 5 Plate - DYC3038-5 from R&D Systems Category ELISA Kit

Ephrin type-B receptor 4 (EPHB4), Human, ELISA Kit - CSB-EL007732HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.1 pg/ml Range 12.5 pg/ml-800 pg/ml

Ephrin type-B receptor 4, EPHB4, Human, ELISA Kit - E15039h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Custom Human EphB4 ELISA - ELH-EPHB4 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

EPH receptor B4, ELISA Kit - MBS924137 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Human Ephrin type-B receptor 4(EPHB4) ELISA kit - CSB-EL007732HU from Cusabio Category ELISA Kit Sensitivity 3.12 pg/ml. Range 12.5 pg/ml-800 pg/ml

Human EPHB4 / EPH Receptor B4 ELISA Kit (Custom ELISA) - LS-F17697 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 31.2-2000 pg/ml

Custom Human EphB4 ELISA Kit - orb247132 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human EphB4 ELISA - RAB1441 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Ephrin type-B receptor 4 (EPHB4) ELISA Kit - EKC33589 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

Custom Human EphB4 ELISA - ELH-EPHB4-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Phosphotyrosine EphB4 ELISA - PEL-EPHB4-Y-1 from RayBiotech Category ELISA Kit Prices $398.00, $716.40, $1,592.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human EPHB4 ELISA Kit - E013303 from Biobool Category ELISA Kit Sensitivity 3.12 pg/ml

EPHB4 ELISA Kit (Human) (OKEH05438) - OKEH05438 from Aviva Systems Biology Category ELISA Kit Prices $500.00 Sizes 96 wells Sensitivity 7.8 pg/mL Range 15.6-1,000 pg/mL

anti-EphB4 antibody - ARG57429 from Arigo Biolaboratories Category ELISA Kit

Tyrosine Kinase B (TRKB), ELISA Kit - MBS9355323 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine Kinase B (TRKB), ELISA Kit - MBS9351818 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine Kinase B (TRKB), ELISA Kit - MBS9361478 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine Kinase B (TRKB), ELISA Kit - MBS9363624 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more