EPHB4

Gene Symbol	EPHB4
Entrez Gene	2050
Alt Symbol	HTK, MYK1, TYRO11
Species	Human
Gene Type	protein-coding
Description	EPH receptor B4
Other Description	ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK
Swissprots	B5A970 P54760 B5A971 Q7Z635 Q9BXP0 Q9BTA5 B5A972
Accessions	AAK21010 AAL14194 CAT16953 EAL23820 EAW76468 EAW76469 EAW76470 P54760 AB209644 BAD92881 AK301224 BAG62797 AY056048 AAL14195 BC004264 AAH04264 BC052804 AAH52804 CB962032 EU826608 ACF47644 EU826609 ACF47645 EU826610 ACF47646 U07695 AAA20598 NM_004444 NP_004435
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
Tissue Specificity	Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Eph receptor B4 protein fragment - ab85713 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Eph receptor B4 protein fragment - ab126932 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human Eph receptor B4 protein fragment - ab167746 from Abcam Category Protein Prices $410.00 Sizes 200 µg Source HEK 293 cells Species Human

Active human Eph receptor B4 protein fragment - ab42608 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Eph receptor B4 peptide - ab107107 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Eph receptor B4 full length protein - ab132955 from Abcam Category Protein Source Wheat germ Species Human

Human Eph receptor B4 protein fragment - ab158377 from Abcam Category Protein Source Wheat germ Species Human

EPHB4 / EPH Receptor B4 Antibody Blocking Peptide - LS-E3520 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPHB4 / EPH Receptor B4 Antibody Blocking Peptide - LS-E26504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EphB4 Partial Recombinant Protein - H00002050-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EphB4 Recombinant Protein - H00002050-P01 from Novus Biologicals Category Protein

EphB4 Recombinant Protein - P4685 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

EphB4-Antibody-Blocking-Protein - BP7625d from Abgent, a WuXi AppTec company Category Protein Prices $80.00 Sizes 100 µg

EphB4 (aa 566 - 578) blocking peptide - GTX88938-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

EphB4 (aa 568 - 581) blocking peptide - GTX89291-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Recombinant Human EphB4, CF - 3038-B4-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu16-Ala539, with a C-terminal 6-His tag

Human EphB4 protein - orb82984 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human EphB4 protein (GST Tag) - orb138789 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human EphB4 His tag protein - orb82983 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

Human EphB4 Fc tag protein - orb82982 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source Human Species Human

EPHB4 Immunizing peptide - orb17190 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

EPHB4 Blocking Peptide - abx062108 from Abbexa Category Peptide Species Human, Mouse, Rat

Eph Receptor B4 Peptide - AC21-1340-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EPHB4 - H00002050-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

EPHB4 - H00002050-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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