EPHB4

Gene Symbol	EPHB4
Entrez Gene	2050
Alt Symbol	HTK, MYK1, TYRO11
Species	Human
Gene Type	protein-coding
Description	EPH receptor B4
Other Description	ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK
Swissprots	B5A970 P54760 B5A971 Q7Z635 Q9BXP0 Q9BTA5 B5A972
Accessions	AAK21010 AAL14194 CAT16953 EAL23820 EAW76468 EAW76469 EAW76470 P54760 AB209644 BAD92881 AK301224 BAG62797 AY056048 AAL14195 BC004264 AAH04264 BC052804 AAH52804 CB962032 EU826608 ACF47644 EU826609 ACF47645 EU826610 ACF47646 U07695 AAA20598 NM_004444 NP_004435
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
Tissue Specificity	Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPHB4 - MBS1270720 from MyBioSource Species Human Accession BC052804

Human EPHB4 cDNA clone(NM_004444.4) - CDFH006009 from Creative Biomart Species Human Accession NM_004444.4

Human EPHB4 cDNA clone(NM_004444.4) - CDFH006010 from Creative Biomart Species Human Accession NM_004444.4

Human EphB4 ORF clone(NM_004444.4) - CDCL184077 from Creative Biomart Species Human Accession NM_004444.4

Human EPHB4 ORF Clone(NM_004444.4) - CDCR288022 from Creative Biomart Species Human Accession NM_004444.4

Human EPHB4 ORF Clone(NM_004444.4) - CDCR288023 from Creative Biomart Species Human Accession NM_004444.4

Human EPHB4 ORF Clone(NM_004444.4) - CDCR288024 from Creative Biomart Species Human Accession NM_004444.4

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone in cloning vector - HG10235-M from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid - HG10235-UT from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10235-CY from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10235-NF from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10235-CH from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10235-CF from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10235-NM from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10235-NY from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10235-CM from Sino Biological Species Human

Human EphB4 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10235-M-F from Sino Biological Species Human Accession NM_004444.4

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10235-ACR from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10235-ACG from Sino Biological Species Human

Human EphB4/Eph Receptor B4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10235-NH from Sino Biological Species Human

Human EphB4 ORF clone(NM_004444.4) - CDCL184077 from Creative biogene Species Human

Human EPHB4 ORF Clone (BC052804) - CDCS411786 from Creative biogene Species Human Accession P54760

Human EPHB4 cDNA Clone(NM_004444.4) - CDFH006009 from Creative biogene Species Human

Human EPHB4 cDNA Clone(NM_004444.4) - CDFH006010 from Creative biogene Species Human

Human EphB4 gene - orb90828 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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