EPHB4

Gene Symbol	EPHB4
Entrez Gene	2050
Alt Symbol	HTK, MYK1, TYRO11
Species	Human
Gene Type	protein-coding
Description	EPH receptor B4
Other Description	ephrin receptor EphB4|ephrin type-B receptor 4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3|tyrosine-protein kinase TYRO11|tyrosine-protein kinase receptor HTK
Swissprots	B5A970 P54760 B5A971 Q7Z635 Q9BXP0 Q9BTA5 B5A972
Accessions	AAK21010 AAL14194 CAT16953 EAL23820 EAW76468 EAW76469 EAW76470 P54760 AB209644 BAD92881 AK301224 BAG62797 AY056048 AAL14195 BC004264 AAH04264 BC052804 AAH52804 CB962032 EU826608 ACF47644 EU826609 ACF47645 EU826610 ACF47646 U07695 AAA20598 NM_004444 NP_004435
Function	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. {ECO:0000269|PubMed:12734395, ECO:0000269|PubMed:16424904}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
Tissue Specificity	Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. {ECO:0000269|PubMed:8188704}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPHB4 293 Cell Lysate - 408406 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

EphB4 Overexpression Lysate (Native) - NBL1-10293 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EPHB4 Over-expression Lysate Product - GWB-A2539B from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human EphB4 / HTK HEK293 Cell Lysate (WB positive control) - 10235-HCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human EphB4 / HTK (aa 563-987) Insect Cell Lysate (WB positive control) - 10235-H20B1L-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human EphB4 / HTK HEK293 Cell Lysate (WB positive control) - 10235-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human EphB4 / HTK HEK293 Cell Lysate (WB positive control) - 10235-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human EphB4 Human Cells Transfected Lysate (positive control) (denatured) - orb172886 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human EPHB4 (aa 563-987) Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175571 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human EphB4 Human Cells Transfected Lysate (positive control) (denatured) - orb172887 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human EphB4 Human Cells Transfected Lysate (positive control) (denatured) - orb172885 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human EPHB4 Knockdown Stable Cell Line - CSC-DC004995 from Creative biogene Category Cell Line Species Human

Human EPHB4 Knockout Cell Line-HEK293T - CSC-RT1651 from Creative biogene Category Cell Line Species Human

EPHB4 KO Cell Lysate-HEK293T - CLKO-0708 from Creative biogene Category Cell Lysate

EPHB4 KO Cell Lysate-HEK293T - CLKO-1498 from Creative biogene Category Cell Lysate

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