| Gene Symbol |
RNASEH2C
|
| Entrez Gene |
84153
|
| Alt Symbol |
AGS3, AYP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease H2, subunit C
|
| Other Description |
RNase H1 small subunit|RNase H2 subunit C|aicardi-Goutieres syndrome 3 protein|ribonuclease H2 subunit C|ribonuclease HI subunit C
|
| Swissprots |
Q8TDP1 Q9H7F5
|
| Accessions |
AAO49176 EAW74433 EAW74434 EAW74435 Q8TDP1 AF312034 AAL87739 AF346606 AAO49177 AK024627 BAB14937 AK225131 AK297660 BAG60026 BC000831 BC023588 AAH23588 BC061891 BM921525 DQ892277 ABM83203 DQ895477 ABM86403 L08647 NM_032193 NP_115569
|
| Function |
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:16845400}.
|
| Top Pathways |
DNA replication
|