Gene Symbol | RNASEH2C |
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Entrez Gene | 84153 |
Alt Symbol | AGS3, AYP1 |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease H2, subunit C |
Other Description | RNase H1 small subunit|RNase H2 subunit C|aicardi-Goutieres syndrome 3 protein|ribonuclease H2 subunit C|ribonuclease HI subunit C |
Swissprots | Q8TDP1 Q9H7F5 |
Accessions | AAO49176 EAW74433 EAW74434 EAW74435 Q8TDP1 AF312034 AAL87739 AF346606 AAO49177 AK024627 BAB14937 AK225131 AK297660 BAG60026 BC000831 BC023588 AAH23588 BC061891 BM921525 DQ892277 ABM83203 DQ895477 ABM86403 L08647 NM_032193 NP_115569 |
Function | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:16845400, ECO:0000269|PubMed:21177858}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:16845400}. |
Top Pathways | DNA replication |
RNase HII-C CRISPR/Cas9 KO Plasmid (h) - sc-413565 from Santa Cruz Biotechnology
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RNase HII-C HDR Plasmid (h) - sc-413565-HDR from Santa Cruz Biotechnology
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RNase HII-C Double Nickase Plasmid (h) - sc-413565-NIC from Santa Cruz Biotechnology
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RNase HII-C Double Nickase Plasmid (h2) - sc-413565-NIC-2 from Santa Cruz Biotechnology
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RNase HII-C CRISPR Activation Plasmid (h) - sc-413565-ACT from Santa Cruz Biotechnology
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RNase HII-C CRISPR Activation Plasmid (h2) - sc-413565-ACT-2 from Santa Cruz Biotechnology
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RNase HII-C Lentiviral Activation Particles (h) - sc-413565-LAC from Santa Cruz Biotechnology
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RNase HII-C Lentiviral Activation Particles (h2) - sc-413565-LAC-2 from Santa Cruz Biotechnology
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RNase HII-C siRNA (h) - sc-62956 from Santa Cruz Biotechnology
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RNase HII-C shRNA Plasmid (h) - sc-62956-SH from Santa Cruz Biotechnology
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RNase HII-C shRNA (h) Lentiviral Particles - sc-62956-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18355 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18355 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11043 from Sigma-Aldrich
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RNASEH2C siRNA (Human) - CRJ3325 from Cohesion Biosciences
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RNASEH2C - MBS8221645 from MyBioSource
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shRNA set against Human RNASEH2C (NM_032193.3) - SHH396396 from Creative biogene
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shRNA set against Human RNASEH2C(NM_032193.3) - SHR184228 from Creative biogene
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RNASEH2C shRNA Plasmid (Human) - CHJ3325 from Cohesion Biosciences
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RNASEH2C miRNA 3'UTR clone - MiUTR1H-08863 from Creative biogene
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