IGFBP3

Gene Symbol	IGFBP3
Entrez Gene	3486
Alt Symbol	BP-53, IBP3
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor binding protein 3
Other Description	IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Swissprots	D3DVM0 A4D2F5 Q9UCL4 Q2V509 P17936 Q6P1M6
Accessions	AAA52706 AAS07554 ABB96247 EAL23801 EAW61025 EAW61026 EAW61027 EAW61028 EAW61029 P17936 AF370418 AAQ15254 AI142967 AK055632 AK056274 BAG51662 AK075483 BAG52153 AK091706 BAG52402 AK091745 BAG52410 AK092447 BAG52553 AK095408 AK095864 AK095869 BAG53151 AK095900 BAG53162 AK095907 AK095974 BAG53182 AK095991 BAG53189 AK097201 AK122873 BAG53771 AK123735 BAG53948 AK125224 BAG54169 AK127537 BAC87023 AK129951 AK130884 AK297767 BAG60115 AK298143 BAG60419 AK315668 BAG38033 AL540642 AU102436 BC000013 AAH00013 BC018962 AAH18962 BC064987 AAH64987 BX640961 DQ884396 ABI63363 DQ884397 ABI63364 DQ884398 ABI63365 DQ895344 ABM86270 M31159 AAA52541 S56205 X64875 CAA46087 NM_000598 NP_000589 NM_001013398 NP_001013416
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Subcellular Location	Secreted {ECO:0000269|PubMed:20353938}.
Tissue Specificity	Expressed by most tissues. Present in plasma.
Top Pathways	p53 signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IGFBP3 Human ELISA Kit - ab100541 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 80 pg/ml Range 74.07 pg/ml - 18000 pg/ml

IGFBP3 Human SimpleStep ELISA™ Kit - ab190809 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 46.4 pg/ml Range 109 pg/ml - 7000 pg/ml

Mouse IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F2457 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Sensitivity 10 pg/ml Range 80-18000 pg/ml

Human IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F2456 from LifeSpan Bioscience Category ELISA Kit Prices $510.00 Sizes 1 plate Sensitivity 10 pg/ml Range 80-18000 pg/ml

Human IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F5076 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 2.52 ng/ml Range 80-18000 pg/ml

Mouse IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F5077 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 1.9 ng/ml Range 80-18000 pg/ml

Bovine IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F6026 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.251 ng/ml Range 80-18000 pg/ml

Rat IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F5477 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 80-18000 pg/ml

Pig IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F5344 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.138 ng/ml Range 80-18000 pg/ml

Human IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F105 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 80 pg/ml Range 80-18000 pg/ml

Mouse/Human IGFBP3 ELISA Kit (Cell-Based ELISA) - LS-F2069 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 80-18000 pg/ml

Mouse IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F250 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 54.87 pg/ml Range 80-18000 pg/ml

Human IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F706 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 80-18000 pg/ml

Mouse IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F10268 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 0.196 ng/ml Range 80-18000 pg/ml

Human IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F11694 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 125 Range 80-18000 pg/ml

Rat IGFBP3 ELISA Kit (Sandwich ELISA) - LS-F11693 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 80-18000 pg/ml

Human IGFBP-3 ELISA Kit - RAB0235 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human IGFBP-3 Quantikine ELISA Kit - DGB300 from R&D Systems Category ELISA Kit Prices $479.00, $2,290.00, $15,560.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 0.14 ng/mL Range 0.8 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human IGFBP-3 Quantikine PharmPak (50 Plates) - PDGB300 from R&D Systems Category ELISA Kit Sensitivity 0.14 ng/mL Range 0.781 - 50 ng/mL (Serum, Heparin Plasma, Cell Culture Supernates, EDTA Plasma)

Human IGFBP-3 Quantikine SixPak (6 Plates) - SGB300 from R&D Systems Category ELISA Kit Sensitivity 0.14 ng/mL Range 0.781 - 50 ng/mL (Serum, Heparin Plasma, Cell Culture Supernates, EDTA Plasma)

Mouse IGFBP-3 Quantikine ELISA Kit - MGB300 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 16 pg/mL Range 78.1 - 5,000 pg/mL (Cell Culture Supernates, EDTA Plasma)

Human IGFBP-3 DuoSet ELISA - DY675 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Mouse IGFBP-3 DuoSet ELISA - DY775 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human IGFBP3 ELISA kit - 55R-1600 from Fitzgerald Category ELISA Kit Prices $385.00 Sizes 1 kit

Mouse IGFBP3 ELISA kit - 55R-1601 from Fitzgerald Category ELISA Kit Prices $415.00 Sizes 1 kit

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