IGFBP3

Gene Symbol	IGFBP3
Entrez Gene	3486
Alt Symbol	BP-53, IBP3
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor binding protein 3
Other Description	IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Swissprots	D3DVM0 A4D2F5 Q9UCL4 Q2V509 P17936 Q6P1M6
Accessions	AAA52706 AAS07554 ABB96247 EAL23801 EAW61025 EAW61026 EAW61027 EAW61028 EAW61029 P17936 AF370418 AAQ15254 AI142967 AK055632 AK056274 BAG51662 AK075483 BAG52153 AK091706 BAG52402 AK091745 BAG52410 AK092447 BAG52553 AK095408 AK095864 AK095869 BAG53151 AK095900 BAG53162 AK095907 AK095974 BAG53182 AK095991 BAG53189 AK097201 AK122873 BAG53771 AK123735 BAG53948 AK125224 BAG54169 AK127537 BAC87023 AK129951 AK130884 AK297767 BAG60115 AK298143 BAG60419 AK315668 BAG38033 AL540642 AU102436 BC000013 AAH00013 BC018962 AAH18962 BC064987 AAH64987 BX640961 DQ884396 ABI63363 DQ884397 ABI63364 DQ884398 ABI63365 DQ895344 ABM86270 M31159 AAA52541 S56205 X64875 CAA46087 NM_000598 NP_000589 NM_001013398 NP_001013416
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Subcellular Location	Secreted {ECO:0000269|PubMed:20353938}.
Tissue Specificity	Expressed by most tissues. Present in plasma.
Top Pathways	p53 signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IGFBP3 overexpression lysate - LY422966 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IGFBP-3 Overexpression Lysate (Native) - NBP2-08719 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cynomolgus IGFBP3 HEK293 Cell Lysate (WB positive control) - 90084-C07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human IGFBP3 / IBP3 HEK293 Cell Lysate (WB positive control) - 10430-H07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IGFBP3 Human Cells Transfected Lysate (positive control) (denatured) - orb172930 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human IGFBP3 Knockdown Stable Cell Line - CSC-DC007486 from Creative biogene Category Cell Line Species Human

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