IGFBP3

Gene Symbol	IGFBP3
Entrez Gene	3486
Alt Symbol	BP-53, IBP3
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor binding protein 3
Other Description	IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Swissprots	D3DVM0 A4D2F5 Q9UCL4 Q2V509 P17936 Q6P1M6
Accessions	AAA52706 AAS07554 ABB96247 EAL23801 EAW61025 EAW61026 EAW61027 EAW61028 EAW61029 P17936 AF370418 AAQ15254 AI142967 AK055632 AK056274 BAG51662 AK075483 BAG52153 AK091706 BAG52402 AK091745 BAG52410 AK092447 BAG52553 AK095408 AK095864 AK095869 BAG53151 AK095900 BAG53162 AK095907 AK095974 BAG53182 AK095991 BAG53189 AK097201 AK122873 BAG53771 AK123735 BAG53948 AK125224 BAG54169 AK127537 BAC87023 AK129951 AK130884 AK297767 BAG60115 AK298143 BAG60419 AK315668 BAG38033 AL540642 AU102436 BC000013 AAH00013 BC018962 AAH18962 BC064987 AAH64987 BX640961 DQ884396 ABI63363 DQ884397 ABI63364 DQ884398 ABI63365 DQ895344 ABM86270 M31159 AAA52541 S56205 X64875 CAA46087 NM_000598 NP_000589 NM_001013398 NP_001013416
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Subcellular Location	Secreted {ECO:0000269|PubMed:20353938}.
Tissue Specificity	Expressed by most tissues. Present in plasma.
Top Pathways	p53 signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IGFBP3 full length protein - ab88368 from Abcam Category Protein Prices $105.00, $1,113.00 Sizes 1 µg, 50 µg Source HEK 293 cells Species Human

Active human IGFBP3 full length protein - ab200302 from Abcam Category Protein Prices $101.00 Sizes 5 µg Source E. coli Species Human

Active human IGFBP3 full length protein - ab192164 from Abcam Category Protein Prices $192.00 Sizes 25 µg Source E. coli Species Human

Human IGFBP3 full length protein - ab155611 from Abcam Category Protein Source HEK 293 cells Species Human

Human IGFBP3 full length protein - ab202241 from Abcam Category Protein Source E. coli Species Human

Human IGFBP3 full length protein - ab182827 from Abcam Category Protein Source E. coli Species Human

Human IGFBP3 protein fragment - ab49831 from Abcam Category Protein Source E. coli Species Human

IGFBP3 peptide - ab156648 from Abcam Category Peptide

IGFBP3 Antibody Blocking Peptide - LS-E9143 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IGFBP3 Antibody Blocking Peptide - LS-E9142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IGFBP3 Antibody Blocking Peptide - LS-E26450 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IGFBP-3 Protein - NBP2-35003 from Novus Biologicals Category Protein Prices $69.00, $149.00, $2,669.00 Sizes 5 µg, 25 µg, 1 mg Source E. coli Species Human

IGFBP-3 Partial Recombinant Protein - H00003486-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IGFBP-3 Recombinant Protein - P4128 from Novus Biologicals Category Protein Prices $549.00 Sizes 25 µg Species Human

Recombinant Human IGFBP-3 Protein - NBP1-99376 from Novus Biologicals Category Protein Prices $190.00 Sizes 25 µg Source E. coli Species Human

IGFBP-3 Protein - NBP1-99681 from Novus Biologicals Category Protein Species Human

IGFBP3-Antibody-S183-Blocking-Peptide - BP7641d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IGFBP3-Antibody-N-term-Blocking-Peptide - BP7641a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IGFBP3 recombinant protein - GTX65124 from GeneTex Category Protein Prices $249.00 Sizes 25 μg Source E. coli Species Human

IGFBP3 Recombinant Protein (Active) - GTX48432-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

IGFBP3 blocking peptide - GTX88951-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human IGFBP-3, CF - 675-B3-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly28-Lys291, with an N-terminal Met

IGFBP 3 Protein (OPPA00565) - OPPA00565 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human IGFBP3 protein - orb82711 from Biorbyt Category Protein Prices $2,125.00 Sizes 1 mg Source E.coli

Human IGFBP3 protein - orb245879 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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