IGFBP3

Gene Symbol IGFBP3
Entrez Gene 3486
Alt Symbol BP-53, IBP3
Species Human
Gene Type protein-coding
Description insulin-like growth factor binding protein 3
Other Description IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Swissprots D3DVM0 A4D2F5 Q9UCL4 Q2V509 P17936 Q6P1M6
Accessions AAA52706 AAS07554 ABB96247 EAL23801 EAW61025 EAW61026 EAW61027 EAW61028 EAW61029 P17936 AF370418 AAQ15254 AI142967 AK055632 AK056274 BAG51662 AK075483 BAG52153 AK091706 BAG52402 AK091745 BAG52410 AK092447 BAG52553 AK095408 AK095864 AK095869 BAG53151 AK095900 BAG53162 AK095907 AK095974 BAG53182 AK095991 BAG53189 AK097201 AK122873 BAG53771 AK123735 BAG53948 AK125224 BAG54169 AK127537 BAC87023 AK129951 AK130884 AK297767 BAG60115 AK298143 BAG60419 AK315668 BAG38033 AL540642 AU102436 BC000013 AAH00013 BC018962 AAH18962 BC064987 AAH64987 BX640961 DQ884396 ABI63363 DQ884397 ABI63364 DQ884398 ABI63365 DQ895344 ABM86270 M31159 AAA52541 S56205 X64875 CAA46087 NM_000598 NP_000589 NM_001013398 NP_001013416
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Subcellular Location Secreted {ECO:0000269|PubMed:20353938}.
Tissue Specificity Expressed by most tissues. Present in plasma.
Top Pathways p53 signaling pathway, Transcriptional misregulation in cancer

IGFBP3 CRISPR/Cas9 KO Plasmid (h) - sc-400682 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 HDR Plasmid (h) - sc-400682-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 Double Nickase Plasmid (h) - sc-400682-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 Double Nickase Plasmid (h2) - sc-400682-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 CRISPR Activation Plasmid (h) - sc-400682-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 CRISPR Activation Plasmid (h2) - sc-400682-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 Lentiviral Activation Particles (h) - sc-400682-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 Lentiviral Activation Particles (h2) - sc-400682-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 siRNA (h) - sc-39587 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGFBP3 shRNA Plasmid (h) - sc-39587-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGFBP3 shRNA (h) Lentiviral Particles - sc-39587-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IGFBP-3 RNAi - H00003486-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IGFBP-3 RNAi - H00003486-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU132051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10522 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10522 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IGFBP3 siRNA (Human) - CRH2357 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IGFBP3 - MBS826849 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IGFBP3 CRISPR/Cas9 KO Plasmid (h2) - sc-400682-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IGFBP3 HDR Plasmid (h2) - sc-400682-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human IGFBP3 (NM_000598.4) - SHH317553 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IGFBP3(NM_001013398.1) - SHL168348 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human IGFBP3(NM_000598.4) - SHL168366 from Creative biogene

Category siRNA
Species Reactivities Human

Human IGFBP3 siRNA - orb262859 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IGFBP3 shRNA Plasmid (Human) - CHH2357 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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