IGFBP3

Gene Symbol IGFBP3
Entrez Gene 3486
Alt Symbol BP-53, IBP3
Species Human
Gene Type protein-coding
Description insulin-like growth factor binding protein 3
Other Description IBP-3|IGF-binding protein 3|IGFBP-3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein|insulin-like growth factor-binding protein 3
Swissprots D3DVM0 A4D2F5 Q9UCL4 Q2V509 P17936 Q6P1M6
Accessions AAA52706 AAS07554 ABB96247 EAL23801 EAW61025 EAW61026 EAW61027 EAW61028 EAW61029 P17936 AF370418 AAQ15254 AI142967 AK055632 AK056274 BAG51662 AK075483 BAG52153 AK091706 BAG52402 AK091745 BAG52410 AK092447 BAG52553 AK095408 AK095864 AK095869 BAG53151 AK095900 BAG53162 AK095907 AK095974 BAG53182 AK095991 BAG53189 AK097201 AK122873 BAG53771 AK123735 BAG53948 AK125224 BAG54169 AK127537 BAC87023 AK129951 AK130884 AK297767 BAG60115 AK298143 BAG60419 AK315668 BAG38033 AL540642 AU102436 BC000013 AAH00013 BC018962 AAH18962 BC064987 AAH64987 BX640961 DQ884396 ABI63363 DQ884397 ABI63364 DQ884398 ABI63365 DQ895344 ABM86270 M31159 AAA52541 S56205 X64875 CAA46087 NM_000598 NP_000589 NM_001013398 NP_001013416
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.
Subcellular Location Secreted {ECO:0000269|PubMed:20353938}.
Tissue Specificity Expressed by most tissues. Present in plasma.
Top Pathways p53 signaling pathway, Transcriptional misregulation in cancer

IGFBP3 Antibody - 13216 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of concentrated conditioned media from serum-starved A-431 cells, untreated (-) or treated with Human Insulin-like Growth Factor I (hIGF-I) #8917 (100 nM, 12 hr; +), using IGFBP3 Antibody.

IGFBP3 (B-5) - sc-365936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IGFBP3 (B-5): sc-365936. Western blot analysis of human recombinant IGFBP3 fusion protein.

IGFBP3 (C-19) - sc-6003 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGFBP3 (C-19): sc-6003. Western blot analysis of human recombinant IGFBP3.

IGFBP3 (E-9) - sc-374365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IGFBP3 (E-9): sc-374365. Western blot analysis of human recombinant IGFBP3.

IGFBP3 (H-98) - sc-9028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IGFBP3 (H-98): sc-9028. Immunofluorescence staining of methanol-fixed MIA PaCa-2 cells showing cytoplasmic localization.

IGFBP3 (M-19) - sc-6004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IGFBP3 (M-19): sc-6004. Western blot analysis of human recombinant IGFBP3.

IGFBP3 (4) - sc-135947 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
IGFBP3 (4): sc-135947. Immunofluorescence staining of human fibroblast cells showing cytoplasmic and extracellular localization.

IGFBP3 (A-25) - sc-130786 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IGFBP3 (A-25): sc-130786. Western blot analysis of IGFBP3 expression in non-transfected (A) and human IGFBP3 transfected (B) 293 whole cell lysates.

Anti-IGFBP3 (phospho S183) antibody - ab193224 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IGFBP3 (phospho S183) antibody (ab193224) at 1/500 dilutionLane 1 : rat brain tissue lysateLane 2 : rat brain tissue lysate with the antigen-specific peptide

Anti-IGFBP3 (phospho S183) antibody - ab111931 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111931 at 1/50 dilution staining IGFBP3 in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-IGFBP3 antibody - ab77635 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-IGFBP3 antibody (ab77635) at 0.02 µg/mlLane 1 : human breast cancer lysate (in RIPA buffer)Lane 2 : human breast cancer lysate (in RIPA buffer) with immunizing peptideLysates/proteins at 35 µg per lane.

Anti-IGFBP3 antibody - ab76001 from Abcam

Prices $385.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IGFBP3 antibody (ab76001) at 1/50 dilutionLane 1 : Lysates from non-transfected 293 cells Lane 2 : Lysates form 293 cells transiently transfected with IGFBP3 gene Lysates/proteins at 2 µg per lane.

Anti-IGFBP3 antibody - ab137370 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IGFBP3 antibody (ab137370) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-IGFBP3 antibody - ab36529 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ab36529 staining human fibroblast cells by ICC/IF.  Cells were fixed in formaldehyde, permeabilised in 0.5% triton for 5 min, and blocked with 4% BSA for 1 hour at 20°C.  The primary antibody was diluted 1/200 with 4% BSA/TBST and incubated for 2 hours at 20°C.  An Alexa Fluor® 594 conjugated donkey anti-mouse was used as the secondary antibody.Red fluorescence shows IGFBP3, blue is DNA.See Abreview

Anti-IGFBP3 antibody - ab4248 from Abcam

Prices $372.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 antibody - ab109790 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 antibody (Biotin) - ab84228 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 antibody [MM0342-6U23] - ab89331 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0342-6U23

Anti-IGFBP3 antibody - N-terminal - ab75988 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IGFBP3 antibody - N-terminal (ab75988) at 1/60 dilution + HepG2 cell line lysates at 35 µg

Anti-IGFBP3 Antibody - LS-C7526 from LifeSpan Bioscience

Prices $485.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 Antibody (C-Terminus) - LS-C36900 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 Antibody - LS-C86142 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 Antibody (clone 83.8F9) - LS-C45037 from LifeSpan Bioscience

Prices $845.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 83.8F9

Anti-IGFBP3 Antibody (Biotin) - LS-C104468 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IGFBP3 Antibody - LS-C129458 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
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