| Gene Symbol |
GPC3
|
| Entrez Gene |
2719
|
| Alt Symbol |
DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glypican 3
|
| Other Description |
glypican proteoglycan 3|glypican-3|heparan sulphate proteoglycan|intestinal protein OCI-5|secreted glypican-3
|
| Swissprots |
Q2L880 C9JLE3 Q2L882 G3V1R0 P51654
|
| Accessions |
AAA98131 AAB87062 CAJ44931 CAO00500 CBF57584 EAX11769 EAX11770 EAX11771 P51654 AK222761 BAD96481 AK222766 BAD96486 AK300168 BAG61950 AK310196 AK310689 BC035972 AAH35972 BX329946 DB107651 DQ349136 ABC72125 DQ349137 ABC72126 DQ349138 ABC72127 DQ893658 ABM84584 DQ895822 ABM86748 JQ943686 AFM30911 L47125 AAA98132 L47176 AAB58806 U50410 AAA93471 Z37987 CAA86069 NM_001164617 NP_001158089 NM_001164618 NP_001158090 NM_001164619 NP_001158091 NM_004484 NP_004475
|
| Function |
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. {ECO:0000269|PubMed:17549790}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in lung, liver and kidney.
|
| Top Pathways |
Proteoglycans in cancer
|
![Western Blot: Glypican 3 Overexpression Lysate (Adult Normal) [NBP2-10593] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Glypican 3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7149_Glypican%25203%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10593-img0001.jpg)