Gene Symbol | GPC3 |
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Entrez Gene | 2719 |
Alt Symbol | DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 |
Species | Human |
Gene Type | protein-coding |
Description | glypican 3 |
Other Description | glypican proteoglycan 3|glypican-3|heparan sulphate proteoglycan|intestinal protein OCI-5|secreted glypican-3 |
Swissprots | Q2L880 C9JLE3 Q2L882 G3V1R0 P51654 |
Accessions | AAA98131 AAB87062 CAJ44931 CAO00500 CBF57584 EAX11769 EAX11770 EAX11771 P51654 AK222761 BAD96481 AK222766 BAD96486 AK300168 BAG61950 AK310196 AK310689 BC035972 AAH35972 BX329946 DB107651 DQ349136 ABC72125 DQ349137 ABC72126 DQ349138 ABC72127 DQ893658 ABM84584 DQ895822 ABM86748 JQ943686 AFM30911 L47125 AAA98132 L47176 AAB58806 U50410 AAA93471 Z37987 CAA86069 NM_001164617 NP_001158089 NM_001164618 NP_001158090 NM_001164619 NP_001158091 NM_004484 NP_004475 |
Function | Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. {ECO:0000269|PubMed:17549790}. |
Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}. |
Tissue Specificity | Highly expressed in lung, liver and kidney. |
Top Pathways | Proteoglycans in cancer |
Human-GPC3-cDNA-Clone - DC06976 from Abgent, a WuXi AppTec company
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GPC3 - MBS1266389 from MyBioSource
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Human GPC3 cDNA clone(NM_001164617.1) - CDFH007821 from Creative Biomart
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Human GPC3 cDNA clone(NM_001164619.1) - CDFH007822 from Creative Biomart
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Human GPC3 cDNA clone(NM_001164618.1) - CDFH007823 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164617.1) - CDCL165080 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164617.1) - CDCR354781 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164617.1) - CDCR354782 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164618.1) - CDCR354783 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164618.1) - CDCR354784 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164619.1) - CDCR354785 from Creative Biomart
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Human GPC3 ORF Clone(NM_001164619.1) - CDCR354787 from Creative Biomart
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Human glypican 3 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10088-M-F from Sino Biological
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Human glypican 3 natural ORF mammalian expression plasmid - HG10088-UT from Sino Biological
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Human GPC3 ORF clone (NM_001164617.1) - CDCL113607 from Creative biogene
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Human GPC3 ORF clone (NM_001164618.1) - CDCL113609 from Creative biogene
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Mouse GPC3 ORF clone (NM_001164619.1) - CDCL113611 from Creative biogene
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Human GPC3 ORF Clone (BC035972) - CDCS408765 from Creative biogene
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Human GPC3 cDNA Clone(NM_001164617.1) - CDFH007821 from Creative biogene
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Human GPC3 cDNA Clone(NM_001164619.1) - CDFH007822 from Creative biogene
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Human GPC3 cDNA Clone(NM_001164618.1) - CDFH007823 from Creative biogene
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