| Gene Symbol |
TNPO2
|
| Entrez Gene |
30000
|
| Alt Symbol |
IPO3, KPNB2B, TRN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transportin 2
|
| Other Description |
importin 3|karyopherin beta 2b, transportin|karyopherin beta-2b|transportin 2 (importin 3, karyopherin beta 2b)|transportin-2
|
| Swissprots |
Q6IN77 O14787 O14655
|
| Accessions |
CCQ43422 EAW84299 EAW84300 EAW84301 O14787 AB210011 BAE06093 AF007748 AAB71349 AF019039 AAB83973 AK022217 AK056183 BAG51640 AK299485 BAG61447 AK307632 AL832114 BC018314 AAH18314 BC063679 BC072420 AAH72420 DA100622 DA808781 DC377831 DC407313 F15550 NM_001136195 NP_001129667 NM_001136196 NP_001129668 NM_013433 NP_038461
|
| Function |
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|