Gene Symbol | TNPO2 |
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Entrez Gene | 30000 |
Alt Symbol | IPO3, KPNB2B, TRN2 |
Species | Human |
Gene Type | protein-coding |
Description | transportin 2 |
Other Description | importin 3|karyopherin beta 2b, transportin|karyopherin beta-2b|transportin 2 (importin 3, karyopherin beta 2b)|transportin-2 |
Swissprots | Q6IN77 O14787 O14655 |
Accessions | CCQ43422 EAW84299 EAW84300 EAW84301 O14787 AB210011 BAE06093 AF007748 AAB71349 AF019039 AAB83973 AK022217 AK056183 BAG51640 AK299485 BAG61447 AK307632 AL832114 BC018314 AAH18314 BC063679 BC072420 AAH72420 DA100622 DA808781 DC377831 DC407313 F15550 NM_001136195 NP_001129667 NM_001136196 NP_001129668 NM_013433 NP_038461 |
Function | Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
TNPO2 - MBS1278799 from MyBioSource
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Human TNPO2 cDNA clone(NM_001136195.1) - CDFH020077 from Creative Biomart
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Human TNPO2 cDNA clone(NM_001136196.1) - CDFH020078 from Creative Biomart
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human TNPO2 ORF clone - CDCH093798 from Creative Biomart
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human TNPO2 ORF clone - CDCH093799 from Creative Biomart
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human TNPO2 ORF clone - CDCH093800 from Creative Biomart
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human TNPO2 ORF clone - CDCH093801 from Creative Biomart
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human TNPO2 ORF clone - CDCH093802 from Creative Biomart
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human TNPO2 ORF clone - CDCH093803 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136195.1) - CDCL179297 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136195.1) - CDCL179298 from Creative Biomart
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Human TNPO2 ORF Clone(NM_013433.4) - CDCR296587 from Creative Biomart
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Human TNPO2 ORF Clone(NM_013433.4) - CDCR296588 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136195.1) - CDCR350813 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136195.1) - CDCR350814 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136196.1) - CDCR350815 from Creative Biomart
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Human TNPO2 ORF Clone(NM_001136196.1) - CDCR350816 from Creative Biomart
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Human TNPO2 ORF Clone(NM_013433.4) - CDCR296587 from Creative biogene
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Human TNPO2 ORF Clone(NM_001136195.1) - CDCR350813 from Creative biogene
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human TNPO2 ORF clone (NM_001136196.1) - CDCH093798 from Creative biogene
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Human TNPO2 ORF Clone (BC072420) - CDCS408181 from Creative biogene
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Human TNPO2 cDNA Clone(NM_001136195.1) - CDFH020077 from Creative biogene
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Human TNPO2 cDNA Clone(NM_001136196.1) - CDFH020078 from Creative biogene
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