POLR1B

Gene Symbol	POLR1B
Entrez Gene	84172
Alt Symbol	RPA135, RPA2, Rpo1-2
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) I polypeptide B, 128kDa
Other Description	DNA-directed RNA polymerase I 135 kDa polypeptide|DNA-directed RNA polymerase I 135kDa polypeptide|DNA-directed RNA polymerase I subunit RPA2|RNA polymerase I subunit 2
Swissprots	B7Z823 B7Z6Y7 Q6ZRR2 Q2TAM4 F8W898 F5GZX4 Q9H9D3 Q585T5 Q9H9Y6
Accessions	AAX81999 EAW73590 EAW73591 EAW73592 EAW73593 Q9H9Y6 AA484631 AK001678 BAA91831 AK022533 BAB14082 AK022890 BAB14296 AK025574 BAB15175 AK128044 BAC87247 AK172817 AK294027 BAH11652 AK301178 BAH13423 AK302814 BAH13809 BC004882 AAH04882 BC073857 AAH73857 BC096748 AAH96748 BC110833 AAI10834 BC150139 BX647360 BX647683 NM_001137604 NP_001131076 NM_001282772 NP_001269701 NM_001282774 NP_001269703 NM_001282776 NP_001269705 NM_001282777 NP_001269706 NM_001282779 NP_001269708 NM_019014 NP_061887
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
Top Pathways	Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POLR1B 293 Cell Lysate - 402373 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

POLR1B Overexpression Lysate (Native) - NBL1-14574 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

POLR1B Over-expression Lysate Product - GWB-8E3747 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human POLR1B Knockdown Stable Cell Line - CSC-DC012085 from Creative biogene Category Cell Line Species Human

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