POLR1B

Gene Symbol POLR1B
Entrez Gene 84172
Alt Symbol RPA135, RPA2, Rpo1-2
Species Human
Gene Type protein-coding
Description polymerase (RNA) I polypeptide B, 128kDa
Other Description DNA-directed RNA polymerase I 135 kDa polypeptide|DNA-directed RNA polymerase I 135kDa polypeptide|DNA-directed RNA polymerase I subunit RPA2|RNA polymerase I subunit 2
Swissprots B7Z823 B7Z6Y7 Q6ZRR2 Q2TAM4 F8W898 F5GZX4 Q9H9D3 Q585T5 Q9H9Y6
Accessions AAX81999 EAW73590 EAW73591 EAW73592 EAW73593 Q9H9Y6 AA484631 AK001678 BAA91831 AK022533 BAB14082 AK022890 BAB14296 AK025574 BAB15175 AK128044 BAC87247 AK172817 AK294027 BAH11652 AK301178 BAH13423 AK302814 BAH13809 BC004882 AAH04882 BC073857 AAH73857 BC096748 AAH96748 BC110833 AAI10834 BC150139 BX647360 BX647683 NM_001137604 NP_001131076 NM_001282772 NP_001269701 NM_001282774 NP_001269703 NM_001282776 NP_001269705 NM_001282777 NP_001269706 NM_001282779 NP_001269708 NM_019014 NP_061887
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
Top Pathways Purine metabolism, RNA polymerase, Pyrimidine metabolism

RPA135 (H-15) - sc-17914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA135 (H-15): sc-17914. Western blot analysis of RPA135 expression in K-562 (A) and NIH/3T3 (B) nuclear extracts.

RPA135 (N-17) - sc-17913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA135 (N-17): sc-17913. Western blot analysis of RPA135 expression in HeLa nuclear extract.

Anti-POLR1B antibody - ab113023 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-POLR1B antibody (ab113023) at 1/100 dilution + HeLa cell line lysates at 35 µg

Anti-POLR1B antibody - ab101977 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-POLR1B antibody (ab101977) at 1 µg/ml + ACHN cell lysate at 10 µg

Anti-POLR1B Antibody (aa89-117, AP) - LS-C239283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa89-117, APC) - LS-C239284 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa89-117, Biotin) - LS-C239285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa89-117, FITC) - LS-C239286 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa89-117, Azide-free, HRP) - LS-C248520 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa89-117, PE) - LS-C239287 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa88-117) - LS-C324165 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1B Antibody (aa1007-1056) - LS-C116358 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
POLR1B antibody LS-C116358 Western blot of ACHN lysate.

Anti-POLR1B Antibody (aa89-117) - LS-C163844 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
POLR1B Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

RPA2 Antibody (9A1) - NBP2-02182 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9A1
Western Blot: RPA2 Antibody (9A1) [NBP2-02182] Analysis of extracts (35ug) from 9 different cell lines by usin g anti-RPA2 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

RPA2 Antibody (MA34) - NB100-74526 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone MA34
Western Blot: RPA2 Antibody (MA34) [NB100-74526] - Analysis of purified RPA protein

RPA2 Antibody - NB100-347 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RPA2 Antibody [NB100-347] - Antibody at a dilution of 1:2500 staining RPA 32 in A) HeLa whole cell lysate, B) Raji whole cell lysate and C) NIH-3T3 whole cell lysate by Western Blot (ECL).

POLR1B Antibody - NBP1-53191 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: POLR1B Antibody [NBP1-53191] - Titration: 0.2-1 ug/ml, Positive Control: ACHN cell lysate.

RPA2 Antibody - NB100-157 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
Western Blot: RPA2 Antibody [NB100-157] - Detection of human RPA32 protein using RPA32 mouse polyclonal antiserum shown in lane 1 and RPA32 rabbit polyclonal antiserum shown in lane 2. Western Blot was done using HeLa whole cell extract.

POLR1B Antibody (4H6) - H00084172-M10 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H6
Western Blot: POLR1B Antibody (4H6) [H00084172-M10] - Analysis of POLR1B expression in transfected 293T cell line by POLR1B monoclonal antibody (M10), clone 4H6. Lane 1: POLR1B transfected lysate (Predicted MW: 128.2 KDa). Lane 2: Non-transfected lysate.

POLR1B Antibody - H00084172-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

RPA2 Antibody (MA34) [PerCP] - NB100-74526PCP from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone MA34

RPA2 Antibody (MA34) [DyLight 350] - NB100-74526UV from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone MA34

RPA2 Antibody (MA34) [DyLight 488] - NB100-74526G from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone MA34

RPA2 Antibody (MA34) [DyLight 755] - NB100-74526IR from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone MA34

RPA2 Antibody (MA34) [DyLight 405] - NB100-74526V from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone MA34
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