| Gene Symbol |
KMO
|
| Entrez Gene |
8564
|
| Alt Symbol |
dJ317G22.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
|
| Other Description |
kynurenine 3-hydroxylase|kynurenine 3-monooxygenase
|
| Swissprots |
A2A2V0 O15229 Q5SY09 Q5SY07 A2A2U9 Q5SY08 A2A2U8
|
| Accessions |
EAW70094 EAW70095 EAW70096 O15229 AF056032 AAC62615 AI262990 AK291558 BAF84247 AK310937 AU137977 BC005297 AAH05297 BP276365 CB989076 DB373228 Y13153 CAA73613 XM_005273337 XP_005273394 XM_005273338 XP_005273395 NM_003679 NP_003670
|
| Function |
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
|
| Tissue Specificity |
Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269|PubMed:9237672}.
|
| Top Pathways |
Tryptophan metabolism
|