KMO

Gene Symbol	KMO
Entrez Gene	8564
Alt Symbol	dJ317G22.1
Species	Human
Gene Type	protein-coding
Description	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Other Description	kynurenine 3-hydroxylase|kynurenine 3-monooxygenase
Swissprots	A2A2V0 O15229 Q5SY09 Q5SY07 A2A2U9 Q5SY08 A2A2U8
Accessions	EAW70094 EAW70095 EAW70096 O15229 AF056032 AAC62615 AI262990 AK291558 BAF84247 AK310937 AU137977 BC005297 AAH05297 BP276365 CB989076 DB373228 Y13153 CAA73613 XM_005273337 XP_005273394 XM_005273338 XP_005273395 NM_003679 NP_003670
Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Subcellular Location	Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
Tissue Specificity	Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269|PubMed:9237672}.
Top Pathways	Tryptophan metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human kynurenine 3-monooxygenase full length protein - ab152891 from Abcam Category Protein Source Wheat germ Species Human

KMO Antibody Blocking Peptide - LS-E23342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KMO Antibody Blocking Peptide - LS-E23343 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KMO Antibody Blocking Peptide - LS-E9708 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Kynurenine 3-Monooxygenase/KMO Protein - H00008564-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

KMO-Antibody-Center-Blocking-Peptide - BP8660c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Kynurenine 3-Monooxygenase/KMO, CF - 8050-KM-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Asp2-Leu441, with an N-terminal Met and 6-His tag

Human KMO protein - orb244327 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human KMO protein - orb245900 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Kynurenine 3-monooxygenase / KMO - H00008564-P01-10 from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source in vitro transl. Species Human

Kynurenine 3-monooxygenase / KMO - H00008564-P01-25 from Acris Antibodies Category Protein Prices $460.00 Sizes 25 µg Source in vitro transl. Species Human

KMO fusion protein - ag16661 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

KMO fusion protein - Ag1109 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human KMO - KMO-649H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Kynurenine-3-Monooxygenase (KMO) - RPH755Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Kynurenine-3-Monooxygenase (KMO) - RPH755Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Kynurenine-3-Monooxygenase (KMO) - RPH755Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Kynurenine 3-monooxygenase - CSB-YP012475HU CSB-BP012475HU CSB-MP012475HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Kynurenine 3-monooxygenase - CSB-EP012475HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Kynurenine 3-monooxygenase(kmo) - CSB-YP772810FFT CSB-EP772810FFT CSB-BP772810FFT CSB-MP772810FFT from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Pseudomonas

Recombinant Kynurenine 3-monooxygenase(kmo) - CSB-YP691897XBB CSB-EP691897XBB CSB-BP691897XBB CSB-MP691897XBB from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Xanthomonas

Recombinant Human Kynurenine 3-Monooxygenase/KMO Protein, CF - 8050-KM from R&D Systems Category Protein Prices $329.00 Sizes 25 µg Source Spodoptera frugiperda , Sf 21 (baculovirus)-derived Asp2-Leu441, with an N-terminal Met and 6-His tag Species Human

KMO Protein - abx163112 from Abbexa Category Protein Species Human

Kynurenine 3-monooxygenase / KMO - TP322594 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Kynurenine 3-monooxygenase / KMO (C-term AVI tag) - TP700071 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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