KMO

Gene Symbol KMO
Entrez Gene 8564
Alt Symbol dJ317G22.1
Species Human
Gene Type protein-coding
Description kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Other Description kynurenine 3-hydroxylase|kynurenine 3-monooxygenase
Swissprots A2A2V0 O15229 Q5SY09 Q5SY07 A2A2U9 Q5SY08 A2A2U8
Accessions EAW70094 EAW70095 EAW70096 O15229 AF056032 AAC62615 AI262990 AK291558 BAF84247 AK310937 AU137977 BC005297 AAH05297 BP276365 CB989076 DB373228 Y13153 CAA73613 XM_005273337 XP_005273394 XM_005273338 XP_005273395 NM_003679 NP_003670
Function Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Subcellular Location Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
Tissue Specificity Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269|PubMed:9237672}.
Top Pathways Tryptophan metabolism

KMO CRISPR/Cas9 KO Plasmid (h) - sc-418366 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO HDR Plasmid (h) - sc-418366-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO Double Nickase Plasmid (h) - sc-418366-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO Double Nickase Plasmid (h2) - sc-418366-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO CRISPR Activation Plasmid (h) - sc-418366-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO CRISPR Activation Plasmid (h2) - sc-418366-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO Lentiviral Activation Particles (h) - sc-418366-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO Lentiviral Activation Particles (h2) - sc-418366-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KMO siRNA (h) - sc-88853 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KMO shRNA Plasmid (h) - sc-88853-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KMO shRNA (h) Lentiviral Particles - sc-88853-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN11332 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

KMO siRNA (Human) - CRH5632 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Kynurenine 3-Monooxygenase/KMO RNAi - H00008564-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KMO (NM_003679.4) - SHH326923 from Creative biogene

Category siRNA
Species Reactivities Human

Human KMO siRNA - orb266134 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KMO shRNA Plasmid (Human) - CHH5632 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KMO miRNA 3'UTR clone - MiUTR4H-TG11608 from Creative biogene

Species Reactivities Human
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