KMO

Gene Symbol KMO
Entrez Gene 8564
Alt Symbol dJ317G22.1
Species Human
Gene Type protein-coding
Description kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Other Description kynurenine 3-hydroxylase|kynurenine 3-monooxygenase
Swissprots A2A2V0 O15229 Q5SY09 Q5SY07 A2A2U9 Q5SY08 A2A2U8
Accessions EAW70094 EAW70095 EAW70096 O15229 AF056032 AAC62615 AI262990 AK291558 BAF84247 AK310937 AU137977 BC005297 AAH05297 BP276365 CB989076 DB373228 Y13153 CAA73613 XM_005273337 XP_005273394 XM_005273338 XP_005273395 NM_003679 NP_003670
Function Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Subcellular Location Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:9237672}.
Tissue Specificity Highest levels in placenta and liver. Detectable in kidney. {ECO:0000269|PubMed:9237672}.
Top Pathways Tryptophan metabolism

KMO (S-19) - sc-243224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-kynurenine 3-monooxygenase antibody - ab93195 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-kynurenine 3-monooxygenase antibody (ab93195) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-kynurenine 3-monooxygenase antibody - ab130959 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-kynurenine 3-monooxygenase antibody (ab130959) at 1 µg/ml + OVCAR-3 cell lysate at 10 µg

Anti-kynurenine 3-monooxygenase antibody - ab167274 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-kynurenine 3-monooxygenase antibody (ab167274) at 1 µg/mlLane 1 : Kynurenine 3-monooxygenase transfected 293T cell lysate Lane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-KMO Antibody (N-Terminus) - LS-C209409 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (aa300-400) - LS-C209356 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot of Rabbit anti-KMO antibody. Lane 1: Brain Extract. Load: 10 ug per lane. Primary antibody: KMO antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 58 kDa for KMO. Other band(s): None.

Anti-KMO Antibody (N-Terminus) - LS-C209412 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (aa200-375) - LS-C209420 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (APC) - LS-C225741 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (aa135-184) - LS-C186738 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human 293T. KMO antibody dilution 1.0 ug/ml.

Anti-KMO Antibody (AP) - LS-C225742 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (Biotin) - LS-C225743 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (FITC) - LS-C225744 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (Azide-free, HRP) - LS-C225745 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (aa200-300) - LS-C209357 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot of Rabbit anti-KMO antibody. Lane 1: Brain Extract. Load: 10 ug per lane. Primary antibody: KMO antibody at 1ug/mL for overnight at 4 degrees C. Secondary antibody: IRDye800 alpha rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4 degrees C. Predicted/Observed size: 58 kDa for KMO. Other band(s): Other bands at lower molecular weights. These bands are all specifically blocked by KMO peptide.

Anti-KMO Antibody (PE) - LS-C225746 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody - LS-C308683 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-KMO Antibody (Internal, Azide-free) - LS-C327736 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMO Antibody (N-Terminus) - LS-C151595 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KMO antibody Western Blot of Human Fetal Kidney. Antibody Dilution: 1.0 ug/ml. Antibody dilution: 1 ug/ml.

Anti-KMO Antibody (aa155-182) - LS-C165595 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with KMO Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Kynurenine 3-Monooxygenase/KMO Antibody - NBP1-44263 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Kynurenine 3-Monooxygenase/KMO Antibody [NBP1-44263] - Lane 1: Brain Extract. Load: 10 ug per lane. Primary antibody: KMO antibody at 1ug/mL for overnight at 4C. Secondary antibody: IRDye800 rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4C. Predicted/Observed size: 58 kDa for KMO. Other band(s): None.

Kynurenine 3-Monooxygenase/KMO Antibody - NBP2-29936 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Kynurenine 3-Monooxygenase/KMO Antibody [NBP2-29936] - Antibody (Center) at 1:2000 dilution + mouse liver lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Kynurenine 3-Monooxygenase/KMO Antibody - NBP1-86335 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Kynurenine 3-Monooxygenase/KMO Antibody [NBP1-86335] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Kynurenine 3-Monooxygenase/KMO Antibody - H00008564-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-KMO antibody produced in rabbit - HPA031115 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KMO: <B>Cat. No. HPA031115</B>: Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
Search more