Gene Symbol |
LSM1
|
Entrez Gene |
27257
|
Alt Symbol |
CASM, YJL124C
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
LSM1, U6 small nuclear RNA associated
|
Other Description |
LSM1 homolog, U6 small nuclear RNA associated|U6 snRNA-associated Sm-like protein LSm1|cancer-associated Sm-like protein|small nuclear ribonuclear CaSm
|
Swissprots |
O15116 B2R5E6
|
Accessions |
CBM42914 CBV35647 EAW63332 EAW63333 O15116 AF000177 AAB62189 AF147348 AJ238094 CAB45865 AK312159 BAG35093 BC001767 AAH01767 BE670269 BP376421 BU521199 BU941962 NM_014462 NP_055277 NR_045492 NR_045493
|
Function |
Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. {ECO:0000269|PubMed:18172165}.
|
Subcellular Location |
Nucleus {ECO:0000305}.
|
Tissue Specificity |
Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.
|
Top Pathways |
RNA degradation
|