Gene Symbol | LSM1 |
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Entrez Gene | 27257 |
Alt Symbol | CASM, YJL124C |
Species | Human |
Gene Type | protein-coding |
Description | LSM1, U6 small nuclear RNA associated |
Other Description | LSM1 homolog, U6 small nuclear RNA associated|U6 snRNA-associated Sm-like protein LSm1|cancer-associated Sm-like protein|small nuclear ribonuclear CaSm |
Swissprots | O15116 B2R5E6 |
Accessions | CBM42914 CBV35647 EAW63332 EAW63333 O15116 AF000177 AAB62189 AF147348 AJ238094 CAB45865 AK312159 BAG35093 BC001767 AAH01767 BE670269 BP376421 BU521199 BU941962 NM_014462 NP_055277 NR_045492 NR_045493 |
Function | Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. {ECO:0000269|PubMed:18172165}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Has elevated expression in pancreatic cancer and in several cancer-derived cell lines. |
Top Pathways | RNA degradation |
LSm1 CRISPR/Cas9 KO Plasmid (h) - sc-403980 from Santa Cruz Biotechnology
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LSm1 HDR Plasmid (h) - sc-403980-HDR from Santa Cruz Biotechnology
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LSm1 Double Nickase Plasmid (h) - sc-403980-NIC from Santa Cruz Biotechnology
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LSm1 Double Nickase Plasmid (h2) - sc-403980-NIC-2 from Santa Cruz Biotechnology
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LSm1 CRISPR Activation Plasmid (h) - sc-403980-ACT from Santa Cruz Biotechnology
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LSm1 CRISPR Activation Plasmid (h2) - sc-403980-ACT-2 from Santa Cruz Biotechnology
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LSm1 Lentiviral Activation Particles (h) - sc-403980-LAC from Santa Cruz Biotechnology
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LSm1 Lentiviral Activation Particles (h2) - sc-403980-LAC-2 from Santa Cruz Biotechnology
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LSm1 siRNA (h) - sc-72335 from Santa Cruz Biotechnology
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LSm1 shRNA Plasmid (h) - sc-72335-SH from Santa Cruz Biotechnology
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LSm1 shRNA (h) Lentiviral Particles - sc-72335-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU121391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12792 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12792 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12038 from Sigma-Aldrich
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LSM1 siRNA (Human) - CRH9048 from Cohesion Biosciences
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LSM1 RNAi - H00027257-R01 from Novus Biologicals
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shRNA set against Human LSM1 (NM_014462.2) - SHH335195 from Creative biogene
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Human LSM1 siRNA - orb269550 from Biorbyt
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LSM1 shRNA Plasmid (Human) - CHH9048 from Cohesion Biosciences
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