COPRS
| Gene Symbol | COPRS |
|---|---|
| Entrez Gene | 55352 |
| Alt Symbol | C17orf79, COPR5, HSA272196, TTP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | coordinator of PRMT5, differentiation stimulator |
| Other Description | cooperator of PRMT5|coordinator of PRMT5 and differentiation stimulator |
| Swissprots | A6NP14 Q96EF5 Q9NQ92 Q96P75 E1P656 |
| Accessions | EAW80260 EAW80261 EAW80262 EAW80263 Q9NQ92 AF407672 AAK97661 AJ272196 CAB77267 AK024772 BC012386 AAH12386 BC035483 BQ671018 DB472863 XM_005258000 XP_005258057 NM_018405 NP_060875 |
| Function | Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18404153}. |
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![Western Blot: COPR5 Antibody [NBP2-30884] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_7/22165_COPR5-Antibody-Western-Blot-NBP2-30884-img0002.jpg)
