COPRS

Gene Symbol	COPRS
Entrez Gene	55352
Alt Symbol	C17orf79, COPR5, HSA272196, TTP1
Species	Human
Gene Type	protein-coding
Description	coordinator of PRMT5, differentiation stimulator
Other Description	cooperator of PRMT5\|coordinator of PRMT5 and differentiation stimulator
Swissprots	A6NP14 Q96EF5 Q9NQ92 Q96P75 E1P656
Accessions	EAW80260 EAW80261 EAW80262 EAW80263 Q9NQ92 AF407672 AAK97661 AJ272196 CAB77267 AK024772 BC012386 AAH12386 BC035483 BQ671018 DB472863 XM_005258000 XP_005258057 NM_018405 NP_060875
Function	Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:18404153}.

Category	Protein
Source	Yeast or E.coli or Baculovirus or Mammalian cell
Species	Human

Category	Protein
Prices	$930.00, $930.00, $1,155.00, $1,155.00, $1,390.00, $1,390.00, $1,845.00, $1,845.00
Sizes	500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source	E Coli or Yeast or Baculovirus or Mammalian Cell
Species	Human

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