| Gene Symbol |
COPRS
|
| Entrez Gene |
55352
|
| Alt Symbol |
C17orf79, COPR5, HSA272196, TTP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coordinator of PRMT5, differentiation stimulator
|
| Other Description |
cooperator of PRMT5|coordinator of PRMT5 and differentiation stimulator
|
| Swissprots |
A6NP14 Q96EF5 Q9NQ92 Q96P75 E1P656
|
| Accessions |
EAW80260 EAW80261 EAW80262 EAW80263 Q9NQ92 AF407672 AAK97661 AJ272196 CAB77267 AK024772 BC012386 AAH12386 BC035483 BQ671018 DB472863 XM_005258000 XP_005258057 NM_018405 NP_060875
|
| Function |
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18404153}.
|