RAG2

Gene Symbol	RAG2
Entrez Gene	5897
Alt Symbol	RAG-2
Species	Human
Gene Type	protein-coding
Description	recombination activating gene 2
Other Description	V(D)J recombination-activating protein 2
Swissprots	P55895 Q8TBL4 A8K9E9
Accessions	AAG38705 CCO13799 EAW68117 P55895 AF080577 AAC35287 AK292664 BAF85353 AW058148 BC022397 AAH22397 BM457214 BM463455 DB124002 DB142398 DB143931 DB146077 DB151960 DB165259 DQ892012 ABM82938 DQ895201 ABM86127 S78372 NM_000536 NP_000527 NM_001243785 NP_001230714 NM_001243786 NP_001230715 NR_033666
Function	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process le
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Cells of the B- and T-lymphocyte lineages.
Top Pathways	Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAG2 / RAG-2 ELISA Kit (Sandwich ELISA) - LS-F12467 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.312-20 ng/ml

Recombination Activating Gene 2, RAG-2, Human, ELISA Kit - E-EL-H2320 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

V(D)J recombination-activating protein 2, RAG2, Human, ELISA Kit - E1551h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Recombination Activating Gene 2, RAG-2, Rabbit, ELISA Kit - E-EL-RB2152 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Recombination Activating Gene 2, RAG-2, Chicken, ELISA Kit - E-EL-Ch1019 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Recombination Activating Gene 2, RAG-2, Porcine, ELISA Kit - E-EL-P0569 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Recombination Activating Gene 2, RAG-2, Guinea Pig, ELISA Kit - E-EL-GP0688 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Recombination Activating Gene 2, RAG-2, Monkey, ELISA Kit - E-EL-MK0974 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

RAG2 (Human) IP-WB Antibody Pair - H00005897-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human RAG-2(Recombination Activating Gene 2) ELISA Kit - E-EL-H2320 from Elabscience Category ELISA Kit Sensitivity 9.38 pg/mL Range 15.63—1000 pg/mL

Chicken RAG2 / RAG-2 ELISA Kit (Custom ELISA) - LS-F17979 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Rabbit RAG2 / RAG-2 ELISA Kit - LS-F17980 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Mouse RAG2 / RAG-2 ELISA Kit (Custom ELISA) - LS-F17981 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human RAG-2(Recombination Activating Gene 2) ELISA Kit - E-EL-H2320 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 9.38 pg/mLpg/mL Range 15.63~1000 pg/mL

Human RAG-2 ELISA Kit - abx054150 from Abbexa Category ELISA Kit Sensitivity 0.01 ng/ml Range 0.05 ng/ml - 4 ng/ml

RAG2 - EKH3618 from Nordic BioSite Sensitivity 9.375pg/ml Range 15.625--1000pg/ml

RAG2 ELISA Kit (Human) : 96 Wells (OKEH01116) - OKEH01116 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.12 ng/mL Range 0.312 - 20 ng/mL

Human RAG-2 ELISA Kit - E032772 from Biobool Category ELISA Kit Sensitivity 9.375pg/mL

Human RAG2 ELISA Kit - E095256 from Biobool Category ELISA Kit

Human V(D)J recombination-activating protein 2 ELISA Kit - EK3781 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Sensitivity less than 0.1ng/mL Range 0.312-20 ng/mL

Recombination activating gene 2, ELISA Kit - MBS2605389 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

V (D)J recombination-activating protein 2, ELISA Kit - MBS9427611 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Sensitivity Less than 0.12ng/mL Range 0.312-20 ng/mL

V(D)J recombination-activating protein 2, ELISA Kit - MBS2881540 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.312-20 ng/mL

Recombination Activating Gene 2 (PAG-2), ELISA Kit - MBS9378971 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human RAG2 / RAG-2 ELISA Kit (Sandwich ELISA) - LS-F35759 from LifeSpan Bioscience Category ELISA Kit Sensitivity 9.375 Range 0.312-20 ng/ml

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