RAG2

Gene Symbol	RAG2
Entrez Gene	5897
Alt Symbol	RAG-2
Species	Human
Gene Type	protein-coding
Description	recombination activating gene 2
Other Description	V(D)J recombination-activating protein 2
Swissprots	P55895 Q8TBL4 A8K9E9
Accessions	AAG38705 CCO13799 EAW68117 P55895 AF080577 AAC35287 AK292664 BAF85353 AW058148 BC022397 AAH22397 BM457214 BM463455 DB124002 DB142398 DB143931 DB146077 DB151960 DB165259 DQ892012 ABM82938 DQ895201 ABM86127 S78372 NM_000536 NP_000527 NM_001243785 NP_001230714 NM_001243786 NP_001230715 NR_033666
Function	Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process le
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Cells of the B- and T-lymphocyte lineages.
Top Pathways	Primary immunodeficiency

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAG2 full length protein - ab114779 from Abcam Category Protein Source Wheat germ Species Human

Human RAG2 protein fragment - ab152650 from Abcam Category Protein Source Wheat germ Species Human

RAG2 / RAG-2 Blocking Peptide - LS-E1680 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RAG2 / RAG-2 Antibody Blocking Peptide - LS-E22349 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RAG2 Protein - H00005897-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human RAG2 Protein - H00005897-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAG2-Antibody-C-term-Blocking-peptide - BP12445b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAG2 - H00005897-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAG2 - H00005897-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAG2 - H00005897-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAG2 - H00005897-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAG2 fusion protein - Ag2393 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAG2 fusion protein - Ag16780 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RAG2 - RAG2-29371TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human RAG2, GST-tagged - RAG2-2162H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human V(D)J recombination-activating protein 2 - CSB-YP345128HU CSB-EP345128HU CSB-BP345128HU CSB-MP345128HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

V(D) J recombination-activating protein 2, Recombinant Protein - MBS1173242 from MyBioSource Category Protein Prices $2,175.00, $2,175.00, $2,640.00, $2,640.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAG2 Peptide, Human - M34GP12930H from Creative Peptides Category Peptide Source Synthetic. Species Human

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