RAG2
| Gene Symbol | RAG2 |
|---|---|
| Entrez Gene | 5897 |
| Alt Symbol | RAG-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | recombination activating gene 2 |
| Other Description | V(D)J recombination-activating protein 2 |
| Swissprots | P55895 Q8TBL4 A8K9E9 |
| Accessions | AAG38705 CCO13799 EAW68117 P55895 AF080577 AAC35287 AK292664 BAF85353 AW058148 BC022397 AAH22397 BM457214 BM463455 DB124002 DB142398 DB143931 DB146077 DB151960 DB165259 DQ892012 ABM82938 DQ895201 ABM86127 S78372 NM_000536 NP_000527 NM_001243785 NP_001230714 NM_001243786 NP_001230715 NR_033666 |
| Function | Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process le |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Tissue Specificity | Cells of the B- and T-lymphocyte lineages. |
| Top Pathways | Primary immunodeficiency |
RAG2 293T Cell Transient Overexpression Lysate(Denatured) - H00005897-T01 from Acris Antibodies
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RAG2 overexpression lysate - LY424659 from Acris Antibodies
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RAG2 293 Cell Lysate - 410202 from ABBIOTEC
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RAG2 Overexpression Lysate (Denatured) - H00005897-T01 from Novus Biologicals
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RAG2 Overexpression Lysate (Native) - NBL1-15127 from Novus Biologicals
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RAG2 Over-expression Lysate Product - GWB-32C69B from Genway Biotech
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RAG2 Overexpression Lysate (Denatured) - H00005897-T02 from Novus Biologicals
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Panoply™ Human RAG2 Knockdown Stable Cell Line - CSC-DC012930 from Creative biogene
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